Local plasticity of dendritic excitability can be autonomous of synaptic plasticity and regulated by activity-based phosphorylation of Kv4.2

While plasticity is typically associated with persistent modifications of synaptic strengths, recent studies indicated that modulations of dendritic excitability may form the other part of the engram and dynamically affect computational processing and output of neuronal circuits. However it remains...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e84086-e84086
Hauptverfasser:	Labno, Anna, Warrier, Ajithkumar, Wang, Sheng, Zhang, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Animal euthanasia Animals Back propagation Biology Ca2+/calmodulin-dependent protein kinase II Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Computational neuroscience Dendrites - metabolism Dendritic plasticity Depolarization Engineering Excitability Excitation Experiments Extracellular Signal-Regulated MAP Kinases - metabolism Female Hippocampus - physiology Kinases Laboratory animals Light Long-Term Synaptic Depression Male Memory Neuronal Plasticity - physiology Neurons Neurophysiology Neurosciences Phosphorylation Physics Physiology Plasticity Potassium Potassium channels Potassium channels (voltage-gated) Proteins Pyramidal Cells - physiology Rats Shal Potassium Channels - metabolism Synapses - physiology Synaptic plasticity Synaptic Potentials
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