Type-II myocardial infarction--patient characteristics, management and outcomes
Type-II MI is defined as myocardial infarction (MI) secondary to ischemia due to either increased oxygen demand or decreased supply. This categorization has been used for the last five years, yet, little is known about patient characteristics and clinical outcomes. In the current work we assessed th...
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| description | Type-II MI is defined as myocardial infarction (MI) secondary to ischemia due to either increased oxygen demand or decreased supply. This categorization has been used for the last five years, yet, little is known about patient characteristics and clinical outcomes. In the current work we assessed the epidemiology, causes, management and outcomes of type II MI patients.
A comparative analysis was performed between patients with type-I and type-II MI who participated in two prospective national Acute Coronary Syndrome Israeli Surveys (ACSIS) performed in 2008 and 2010.
The surveys included 2818 patients with acute MI of whom 127 (4.5%) had type-II MI. The main causes of type-II MI were anemia (31%), sepsis (24%), and arrhythmia (17%). Patients with type-II MI tended to be older (75.6±12 vs. 63.8±13, p |
| doi_str_mv | 10.1371/journal.pone.0084285 |
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A comparative analysis was performed between patients with type-I and type-II MI who participated in two prospective national Acute Coronary Syndrome Israeli Surveys (ACSIS) performed in 2008 and 2010.
The surveys included 2818 patients with acute MI of whom 127 (4.5%) had type-II MI. The main causes of type-II MI were anemia (31%), sepsis (24%), and arrhythmia (17%). Patients with type-II MI tended to be older (75.6±12 vs. 63.8±13, p<0.0001), female majority (43.3% vs. 22.3%, p<0.0001), had more frequently impaired functional level (45.7% vs. 17%, p<0.0001) and a higher GRACE risk score (150±32 vs. 110±35, p<0.0001). Patients with type-II MI were significantly less often referred for coronary interventions (36% vs. 89%, p<0.0001) and less frequently prescribed guideline-directed medical therapy. Mortality rates were substantially higher among patients with type-II MI both at thirty-day (13.6% vs. 4.9%, p<0.0001) and at one-year (23.9% vs. 8.6%, p<0.0001) follow-ups.
Patients with type-II compared to type-I MI have distinct demographics, increased prevalence of multiple comorbidities, a high-risk cardiovascular profile and an overall worse outcome. The complex medical condition of this cohort imposes a great therapeutic challenge and specific guidelines with recommended medical treatment and invasive strategies are warranted.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0084285</identifier><identifier>PMID: 24392121</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute coronary syndromes ; Aged ; Aged, 80 and over ; Anemia ; Arrhythmia ; Biology ; Cardiac patients ; Cardiology ; Cardiovascular diseases ; Comparative analysis ; Demographics ; Demography ; Epidemiology ; Female ; Health risks ; Heart attack ; Heart attacks ; Hospitals ; Humans ; Infarction ; Internal medicine ; Ischemia ; Israel - epidemiology ; Male ; Medical research ; Medical treatment ; Medicine ; Middle Aged ; Mortality ; Myocardial infarction ; Myocardial Infarction - diagnosis ; Myocardial Infarction - epidemiology ; Myocardial Infarction - etiology ; Myocardial Infarction - therapy ; Oxygen ; Oxygen demand ; Patient outcomes ; Patients ; Polls & surveys ; Population Surveillance ; Prospective Studies ; Risk Factors ; Sepsis ; Statistical analysis ; Surveys ; Survival Analysis ; Task forces ; Treatment Outcome</subject><ispartof>PloS one, 2014-01, Vol.9 (1), p.e84285-e84285</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Stein et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Stein et al 2014 Stein et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-f57d7ca782cb7be1395b1805f8e6780d1d23491d0c44ccc34b15ba4ce863c23c3</citedby><cites>FETCH-LOGICAL-c758t-f57d7ca782cb7be1395b1805f8e6780d1d23491d0c44ccc34b15ba4ce863c23c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879301/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879301/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24392121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Guo, Yiru</contributor><creatorcontrib>Stein, Gideon Y</creatorcontrib><creatorcontrib>Herscovici, Gabriel</creatorcontrib><creatorcontrib>Korenfeld, Roman</creatorcontrib><creatorcontrib>Matetzky, Shlomi</creatorcontrib><creatorcontrib>Gottlieb, Shmuel</creatorcontrib><creatorcontrib>Alon, Danny</creatorcontrib><creatorcontrib>Gevrielov-Yusim, Natalie</creatorcontrib><creatorcontrib>Iakobishvili, Zaza</creatorcontrib><creatorcontrib>Fuchs, Shmuel</creatorcontrib><title>Type-II myocardial infarction--patient characteristics, management and outcomes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[Type-II MI is defined as myocardial infarction (MI) secondary to ischemia due to either increased oxygen demand or decreased supply. This categorization has been used for the last five years, yet, little is known about patient characteristics and clinical outcomes. In the current work we assessed the epidemiology, causes, management and outcomes of type II MI patients.
A comparative analysis was performed between patients with type-I and type-II MI who participated in two prospective national Acute Coronary Syndrome Israeli Surveys (ACSIS) performed in 2008 and 2010.
The surveys included 2818 patients with acute MI of whom 127 (4.5%) had type-II MI. The main causes of type-II MI were anemia (31%), sepsis (24%), and arrhythmia (17%). Patients with type-II MI tended to be older (75.6±12 vs. 63.8±13, p<0.0001), female majority (43.3% vs. 22.3%, p<0.0001), had more frequently impaired functional level (45.7% vs. 17%, p<0.0001) and a higher GRACE risk score (150±32 vs. 110±35, p<0.0001). Patients with type-II MI were significantly less often referred for coronary interventions (36% vs. 89%, p<0.0001) and less frequently prescribed guideline-directed medical therapy. Mortality rates were substantially higher among patients with type-II MI both at thirty-day (13.6% vs. 4.9%, p<0.0001) and at one-year (23.9% vs. 8.6%, p<0.0001) follow-ups.
Patients with type-II compared to type-I MI have distinct demographics, increased prevalence of multiple comorbidities, a high-risk cardiovascular profile and an overall worse outcome. The complex medical condition of this cohort imposes a great therapeutic challenge and specific guidelines with recommended medical treatment and invasive strategies are warranted.]]></description><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anemia</subject><subject>Arrhythmia</subject><subject>Biology</subject><subject>Cardiac patients</subject><subject>Cardiology</subject><subject>Cardiovascular diseases</subject><subject>Comparative analysis</subject><subject>Demographics</subject><subject>Demography</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health risks</subject><subject>Heart attack</subject><subject>Heart attacks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infarction</subject><subject>Internal medicine</subject><subject>Ischemia</subject><subject>Israel - epidemiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - etiology</subject><subject>Myocardial Infarction - therapy</subject><subject>Oxygen</subject><subject>Oxygen demand</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Polls & surveys</subject><subject>Population Surveillance</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sepsis</subject><subject>Statistical analysis</subject><subject>Surveys</subject><subject>Survival Analysis</subject><subject>Task forces</subject><subject>Treatment Outcome</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7jr6D0QHBFGwYz6b9EZYFj8GFgZ09Takp-lMlrYZk1Scf2_qdJep7IXkIuHkOe_JOXmz7DlGK0wFfn_jBt_rdrV3vVkhJBmR_EF2jktK8oIg-vDkfJY9CeEGIU5lUTzOzgijJcEEn2eb68Pe5Ov1sjs40L62ul3avtEeonV9nu91tKaPS9hpryEab0O0EN4tO93rrenGO93XSzdEcJ0JT7NHjW6DeTbti-z7p4_Xl1_yq83n9eXFVQ6Cy5g3XNQCtJAEKlEZTEteYYl4I00hJKpxTSgrcY2AMQCgrMK80gyMLCgQCnSRvTzq7lsX1DSLoDATVArBC5SI9ZGonb5Re2877Q_Kaav-BpzfKu1TL61RBSk5YlwaApwZXJUVIFJj1DRFEkzDWmQfpmpD1ZkaUtdetzPR-U1vd2rrfqn0mJIinATeTALe_RxMiKqzAUzb6t64YXx3iURatEjoq3_Q-7ubqK1ODaQfc6kujKLqggmZymIhErW6h0qrNp2FZJzGpvgs4e0sITHR_I5bPYSg1t--_j-7-TFnX5-wO6PbuAuuHUaThTnIjiB4F4I3zd2QMVKj72-noUbfq8n3Ke3F6QfdJd0anf4BhUL8ww</recordid><startdate>20140102</startdate><enddate>20140102</enddate><creator>Stein, Gideon Y</creator><creator>Herscovici, Gabriel</creator><creator>Korenfeld, Roman</creator><creator>Matetzky, Shlomi</creator><creator>Gottlieb, Shmuel</creator><creator>Alon, Danny</creator><creator>Gevrielov-Yusim, Natalie</creator><creator>Iakobishvili, Zaza</creator><creator>Fuchs, Shmuel</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140102</creationdate><title>Type-II myocardial infarction--patient characteristics, management and outcomes</title><author>Stein, Gideon Y ; Herscovici, Gabriel ; Korenfeld, Roman ; Matetzky, Shlomi ; Gottlieb, Shmuel ; Alon, Danny ; Gevrielov-Yusim, Natalie ; Iakobishvili, Zaza ; Fuchs, Shmuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-f57d7ca782cb7be1395b1805f8e6780d1d23491d0c44ccc34b15ba4ce863c23c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anemia</topic><topic>Arrhythmia</topic><topic>Biology</topic><topic>Cardiac patients</topic><topic>Cardiology</topic><topic>Cardiovascular diseases</topic><topic>Comparative analysis</topic><topic>Demographics</topic><topic>Demography</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health risks</topic><topic>Heart attack</topic><topic>Heart attacks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infarction</topic><topic>Internal medicine</topic><topic>Ischemia</topic><topic>Israel - epidemiology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - etiology</topic><topic>Myocardial Infarction - therapy</topic><topic>Oxygen</topic><topic>Oxygen demand</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Polls & surveys</topic><topic>Population Surveillance</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sepsis</topic><topic>Statistical analysis</topic><topic>Surveys</topic><topic>Survival Analysis</topic><topic>Task forces</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stein, Gideon Y</creatorcontrib><creatorcontrib>Herscovici, Gabriel</creatorcontrib><creatorcontrib>Korenfeld, Roman</creatorcontrib><creatorcontrib>Matetzky, Shlomi</creatorcontrib><creatorcontrib>Gottlieb, Shmuel</creatorcontrib><creatorcontrib>Alon, Danny</creatorcontrib><creatorcontrib>Gevrielov-Yusim, Natalie</creatorcontrib><creatorcontrib>Iakobishvili, Zaza</creatorcontrib><creatorcontrib>Fuchs, Shmuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stein, Gideon Y</au><au>Herscovici, Gabriel</au><au>Korenfeld, Roman</au><au>Matetzky, Shlomi</au><au>Gottlieb, Shmuel</au><au>Alon, Danny</au><au>Gevrielov-Yusim, Natalie</au><au>Iakobishvili, Zaza</au><au>Fuchs, Shmuel</au><au>Guo, Yiru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type-II myocardial infarction--patient characteristics, management and outcomes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-01-02</date><risdate>2014</risdate><volume>9</volume><issue>1</issue><spage>e84285</spage><epage>e84285</epage><pages>e84285-e84285</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[Type-II MI is defined as myocardial infarction (MI) secondary to ischemia due to either increased oxygen demand or decreased supply. This categorization has been used for the last five years, yet, little is known about patient characteristics and clinical outcomes. In the current work we assessed the epidemiology, causes, management and outcomes of type II MI patients.
A comparative analysis was performed between patients with type-I and type-II MI who participated in two prospective national Acute Coronary Syndrome Israeli Surveys (ACSIS) performed in 2008 and 2010.
The surveys included 2818 patients with acute MI of whom 127 (4.5%) had type-II MI. The main causes of type-II MI were anemia (31%), sepsis (24%), and arrhythmia (17%). Patients with type-II MI tended to be older (75.6±12 vs. 63.8±13, p<0.0001), female majority (43.3% vs. 22.3%, p<0.0001), had more frequently impaired functional level (45.7% vs. 17%, p<0.0001) and a higher GRACE risk score (150±32 vs. 110±35, p<0.0001). Patients with type-II MI were significantly less often referred for coronary interventions (36% vs. 89%, p<0.0001) and less frequently prescribed guideline-directed medical therapy. Mortality rates were substantially higher among patients with type-II MI both at thirty-day (13.6% vs. 4.9%, p<0.0001) and at one-year (23.9% vs. 8.6%, p<0.0001) follow-ups.
Patients with type-II compared to type-I MI have distinct demographics, increased prevalence of multiple comorbidities, a high-risk cardiovascular profile and an overall worse outcome. The complex medical condition of this cohort imposes a great therapeutic challenge and specific guidelines with recommended medical treatment and invasive strategies are warranted.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24392121</pmid><doi>10.1371/journal.pone.0084285</doi><tpages>e84285</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-01, Vol.9 (1), p.e84285-e84285 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1473877560 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acute coronary syndromes Aged Aged, 80 and over Anemia Arrhythmia Biology Cardiac patients Cardiology Cardiovascular diseases Comparative analysis Demographics Demography Epidemiology Female Health risks Heart attack Heart attacks Hospitals Humans Infarction Internal medicine Ischemia Israel - epidemiology Male Medical research Medical treatment Medicine Middle Aged Mortality Myocardial infarction Myocardial Infarction - diagnosis Myocardial Infarction - epidemiology Myocardial Infarction - etiology Myocardial Infarction - therapy Oxygen Oxygen demand Patient outcomes Patients Polls & surveys Population Surveillance Prospective Studies Risk Factors Sepsis Statistical analysis Surveys Survival Analysis Task forces Treatment Outcome |
| title | Type-II myocardial infarction--patient characteristics, management and outcomes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T14%3A29%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Type-II%20myocardial%20infarction--patient%20characteristics,%20management%20and%20outcomes&rft.jtitle=PloS%20one&rft.au=Stein,%20Gideon%20Y&rft.date=2014-01-02&rft.volume=9&rft.issue=1&rft.spage=e84285&rft.epage=e84285&rft.pages=e84285-e84285&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0084285&rft_dat=%3Cgale_plos_%3EA478879177%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1473877560&rft_id=info:pmid/24392121&rft_galeid=A478879177&rft_doaj_id=oai_doaj_org_article_62950458e2c54e1b9bc02d10ff614724&rfr_iscdi=true |