EPC-derived microvesicles protect cardiomyocytes from Ang II-induced hypertrophy and apoptosis

Cell-released microvesicles (MVs) represent a novel way of cell-to-cell communication. Previous evidence indicates that endothelial progenitor cells (EPCs)-derived MVs can modulate endothelial cell survival and proliferation. In this study, we evaluated whether EPC-MVs protect cardiomyocytes (CMs) a...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e85396
Hauptverfasser:	Gu, Shenhong, Zhang, Wei, Chen, Ji, Ma, Ruilian, Xiao, Xiang, Ma, Xiaotang, Yao, Zhen, Chen, Yanfang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Analysis Angiotensin Angiotensin II Angiotensin II - pharmacology Animals Apoptosis Apoptosis - drug effects Biology Cardiology Cardiomyocytes Cell interactions Cell Line Cell proliferation Cell surface Cell survival Cell Survival - drug effects Cell-Derived Microparticles - chemistry Cell-Derived Microparticles - metabolism Cells (biology) Cells, Cultured Diabetes Dose-Response Relationship, Drug Endothelial cells Endothelial Cells - metabolism Endothelium Heart cells Hospitals Hostages Hypertrophy Inhibition Kinases Laboratory animals Medicine Mice Muscle proteins Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myosin Neurology Nitric oxide Nitric Oxide Synthase - metabolism Nitric-oxide synthase Oxidative stress Oxygen Pathogenesis Pharmacology Phosphatidylinositol 3-Kinases - metabolism Protein-serine/threonine kinase Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Reactive oxygen species Reactive Oxygen Species - metabolism RNA - chemistry Rodents Signal Transduction - drug effects Stem cells Stem Cells - metabolism Surface area Threonine Toxicology
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