Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR

Clostridium difficile intestinal disease is mediated largely by the actions of toxins A (TcdA) and B (TcdB), whose production occurs after the initial steps of colonization involving different surface or flagellar proteins. In B. subtilis, the sigma factor SigD controls flagellar synthesis, motility...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e83748-e83748
Hauptverfasser:	El Meouche, Imane, Peltier, Johann, Monot, Marc, Soutourina, Olga, Pestel-Caron, Martine, Dupuy, Bruno, Pons, Jean-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibiotics Autolysins Bacillus subtilis Bacterial Proteins Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Toxins Bacterial Toxins - biosynthesis Bacterial Toxins - genetics Base Sequence Binding Sites Biochemistry, Molecular Biology Biosynthesis Clostridium difficile Clostridium difficile - genetics Clostridium difficile - growth & development Clostridium difficile - metabolism Colonization Consensus Sequence DNA-Directed RNA Polymerases DNA-Directed RNA Polymerases - metabolism E coli Escherichia coli Flagella Flagella - genetics Flagella - metabolism Gastrointestinal diseases Gene expression Gene Expression Regulation, Bacterial Gene sequencing Gene Silencing Genes Genetic Complementation Test Genomes Genomic analysis Genomics Homology Intestine Life Sciences Metabolism Molecular biology Motility Mutation Phenotype Physiological aspects Plasmids Position-Specific Scoring Matrices Promoter Regions, Genetic Promoters (Genetics) Protein Binding Protein Biosynthesis Proteins RNA polymerase Salmonella Salmonella Typhimurium Sigma factor Toxins Transcription Transcription Initiation Site Transcription, Genetic Transcriptome
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