Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: identification of an RGFRRR motif governing fungal cell entry

MtDef4 is a 47-amino acid cysteine-rich evolutionary conserved defensin from a model legume Medicago truncatula. It is an apoplast-localized plant defense protein that inhibits the growth of the ascomycetous fungal pathogen Fusarium graminearum in vitro at micromolar concentrations. Little is known...

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Veröffentlicht in:	PLoS One, 8(12):e82485 8(12):e82485, 2013-12, Vol.8 (12), p.e82485-e82485
Hauptverfasser:	Sagaram, Uma Shankar, El-Mounadi, Kaoutar, Buchko, Garry W, Berg, Howard R, Kaur, Jagdeep, Pandurangi, Raghu S, Smith, Thomas J, Shah, Dilip M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alfalfa Amino Acid Motifs Amino Acid Sequence Amino acids Amino Acids - chemistry Analysis Antifungal activity antifungal agent Antifungal agents Antifungal Agents - chemistry Antifungal Agents - metabolism Antifungal Agents - pharmacology Apoplast Automation Biosynthesis Blood lipids Chemical bonds Cysteine Cytoplasm Defense industry defensins Defensins - chemistry Defensins - metabolism Defensins - pharmacology Environmental Molecular Sciences Laboratory Evolutionary conservation Fungi Fungicides Fusarium Fusarium - drug effects Fusarium - physiology Fusarium - ultrastructure Fusarium graminearum Internalization Labeling Legumes Medicago truncatula - chemistry Medicago truncatula - metabolism membrane dynamics Membrane lipids Membranes Models, Molecular Molecular Sequence Data Nicotiana alata NMR spectroscopy Phosphatidic acid Phosphatidic Acids - metabolism Phospholipids Physiological aspects Plant Proteins - chemistry Plant Proteins - metabolism Plant Proteins - pharmacology Plant sciences Plasma Protein Binding Protein Conformation Proteins Recruitment Sequence Alignment Signaling Static Electricity structural biology Structure-function relationships Studies Translocation
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