Hippocampal glutamate NMDA receptor loss tracks progression in Alzheimer's disease: quantitative autoradiography in postmortem human brain

Early Alzheimer's disease (AD) is characterized by memory loss and hippocampal atrophy with relative sparing of basal ganglia. Activation of glutamate NMDA receptors in the hippocampus is an important step in memory formation. We measured the density of NMDA receptors in samples of hippocampus,...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81244-e81244
Hauptverfasser:	Kravitz, Efrat, Gaisler-Salomon, Inna, Biegon, Anat
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Atrophy Autoradiography Basal ganglia Brain Brain research Cognitive ability Correlation Cortex (entorhinal) Density Disease Progression Female Ganglia Gene expression Glutamic Acid - metabolism Glutamic acid receptors (ionotropic) Hippocampus Hippocampus - metabolism Humans In vivo methods and tests Inflammation Ligands Male Medical imaging Memory N-Methyl-D-aspartic acid receptors Neostriatum Neurodegenerative diseases Neuroimaging Neurology Neurosciences Pollution monitoring Positron emission Positron emission tomography Receptor density Receptors Receptors, N-Methyl-D-Aspartate - deficiency Rodents Studies Tracers Tracks (paths)
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