Airway symptoms and biological markers in nasal lavage fluid in subjects exposed to metalworking fluids
Occurrence of airway irritation among industrial metal workers was investigated. The aims were to study the association between exposures from water-based metal working fluids (MWF) and the health outcome among the personnel, to assess potential effects on the proteome in nasal mucous membranes, and...
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| Veröffentlicht in: | PloS one 2013-12, Vol.8 (12), p.e83089 |
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| creator | Fornander, Louise Graff, Pål Wåhlén, Karin Ydreborg, Kjell Flodin, Ulf Leanderson, Per Lindahl, Mats Ghafouri, Bijar |
| description | Occurrence of airway irritation among industrial metal workers was investigated. The aims were to study the association between exposures from water-based metal working fluids (MWF) and the health outcome among the personnel, to assess potential effects on the proteome in nasal mucous membranes, and evaluate preventive actions.
The prevalence of airway symptoms related to work were examined among 271 metalworkers exposed to MWF and 24 metal workers not exposed to MWF at the same factory. At the same time, air levels of potentially harmful substances (oil mist, morpholine, monoethanolamine, formaldehyde) generated from MWF was measured. Nasal lavage fluid was collected from 13 workers and 15 controls and protein profiles were determined by a proteomic approach.
Airway symptoms were reported in 39% of the workers exposed to MWF although the measured levels of MWF substances in the work place air were low. Highest prevalence was found among workers handling the MWF machines but also those working in the same hall were affected. Improvement of the ventilation to reduce MWF exposure lowered the prevalence of airway problems. Protein profiling showed significantly higher levels of S100-A9 and lower levels of SPLUNC1, cystatin SN, Ig J and β2-microglobulin among workers with airway symptoms.
This study confirms that upper airway symptoms among metal workers are a common problem and despite low levels of MWF-generated substances, effects on airway immune proteins are found. Further studies to clarify the role of specific MWF components in connection to airway inflammation and the identified biological markers are warranted. |
| doi_str_mv | 10.1371/journal.pone.0083089 |
| format | Article |
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The prevalence of airway symptoms related to work were examined among 271 metalworkers exposed to MWF and 24 metal workers not exposed to MWF at the same factory. At the same time, air levels of potentially harmful substances (oil mist, morpholine, monoethanolamine, formaldehyde) generated from MWF was measured. Nasal lavage fluid was collected from 13 workers and 15 controls and protein profiles were determined by a proteomic approach.
Airway symptoms were reported in 39% of the workers exposed to MWF although the measured levels of MWF substances in the work place air were low. Highest prevalence was found among workers handling the MWF machines but also those working in the same hall were affected. Improvement of the ventilation to reduce MWF exposure lowered the prevalence of airway problems. Protein profiling showed significantly higher levels of S100-A9 and lower levels of SPLUNC1, cystatin SN, Ig J and β2-microglobulin among workers with airway symptoms.
This study confirms that upper airway symptoms among metal workers are a common problem and despite low levels of MWF-generated substances, effects on airway immune proteins are found. Further studies to clarify the role of specific MWF components in connection to airway inflammation and the identified biological markers are warranted.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0083089</identifier><identifier>PMID: 24391738</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Air Pollutants, Occupational - adverse effects ; Air Pollutants, Occupational - analysis ; beta 2-Microglobulin - analysis ; Biological markers ; Biology ; Biomarkers ; Biomarkers - analysis ; Calgranulin B - analysis ; Case-Control Studies ; Councils ; Cross-Sectional Studies ; Cystatins ; Environmental health ; Ethanolamines ; Exposure ; Factories ; Female ; Fluids ; Formaldehyde ; Glycoproteins - analysis ; Health aspects ; Health sciences ; Humans ; Immunoglobulin J-Chains - analysis ; Immunoglobulins ; Inhalation Exposure ; Irritants - adverse effects ; Irritants - analysis ; Irritation ; Machinery ; Male ; Medicine ; Membranes ; Metallurgy ; Metalworking fluids ; Metalworking industry ; Middle Aged ; Mist ; Monoethanolamine (MEA) ; Morpholine ; Nasal Lavage Fluid - chemistry ; Neutrophils ; Nitric Oxide - analysis ; Occupational exposure ; Occupational Exposure - adverse effects ; Occupational Exposure - prevention & control ; Occupational health ; Oil mist ; Otolaryngology ; Personnel management ; Phosphoproteins - analysis ; Proteins ; Proteomics ; Questionnaires ; Respiratory tract ; Respiratory tract diseases ; Salivary Cystatins - analysis ; Trends ; Tumor Necrosis Factor-alpha - biosynthesis ; Ventilation ; VOCs ; Volatile organic compounds ; Work environment</subject><ispartof>PloS one, 2013-12, Vol.8 (12), p.e83089</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Fornander et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Fornander et al 2013 Fornander et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c730t-2c7b40c44b3433c1ed9ad73feed76b7805671d7d7dabd8e4bb844b2d9e610d593</citedby><cites>FETCH-LOGICAL-c730t-2c7b40c44b3433c1ed9ad73feed76b7805671d7d7dabd8e4bb844b2d9e610d593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877012/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877012/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24391738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-103739$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Fornander, Louise</creatorcontrib><creatorcontrib>Graff, Pål</creatorcontrib><creatorcontrib>Wåhlén, Karin</creatorcontrib><creatorcontrib>Ydreborg, Kjell</creatorcontrib><creatorcontrib>Flodin, Ulf</creatorcontrib><creatorcontrib>Leanderson, Per</creatorcontrib><creatorcontrib>Lindahl, Mats</creatorcontrib><creatorcontrib>Ghafouri, Bijar</creatorcontrib><title>Airway symptoms and biological markers in nasal lavage fluid in subjects exposed to metalworking fluids</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Occurrence of airway irritation among industrial metal workers was investigated. The aims were to study the association between exposures from water-based metal working fluids (MWF) and the health outcome among the personnel, to assess potential effects on the proteome in nasal mucous membranes, and evaluate preventive actions.
The prevalence of airway symptoms related to work were examined among 271 metalworkers exposed to MWF and 24 metal workers not exposed to MWF at the same factory. At the same time, air levels of potentially harmful substances (oil mist, morpholine, monoethanolamine, formaldehyde) generated from MWF was measured. Nasal lavage fluid was collected from 13 workers and 15 controls and protein profiles were determined by a proteomic approach.
Airway symptoms were reported in 39% of the workers exposed to MWF although the measured levels of MWF substances in the work place air were low. Highest prevalence was found among workers handling the MWF machines but also those working in the same hall were affected. Improvement of the ventilation to reduce MWF exposure lowered the prevalence of airway problems. Protein profiling showed significantly higher levels of S100-A9 and lower levels of SPLUNC1, cystatin SN, Ig J and β2-microglobulin among workers with airway symptoms.
This study confirms that upper airway symptoms among metal workers are a common problem and despite low levels of MWF-generated substances, effects on airway immune proteins are found. Further studies to clarify the role of specific MWF components in connection to airway inflammation and the identified biological markers are warranted.</description><subject>Adult</subject><subject>Air Pollutants, Occupational - adverse effects</subject><subject>Air Pollutants, Occupational - analysis</subject><subject>beta 2-Microglobulin - analysis</subject><subject>Biological markers</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Calgranulin B - analysis</subject><subject>Case-Control Studies</subject><subject>Councils</subject><subject>Cross-Sectional Studies</subject><subject>Cystatins</subject><subject>Environmental health</subject><subject>Ethanolamines</subject><subject>Exposure</subject><subject>Factories</subject><subject>Female</subject><subject>Fluids</subject><subject>Formaldehyde</subject><subject>Glycoproteins - analysis</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Immunoglobulin J-Chains - 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The aims were to study the association between exposures from water-based metal working fluids (MWF) and the health outcome among the personnel, to assess potential effects on the proteome in nasal mucous membranes, and evaluate preventive actions.
The prevalence of airway symptoms related to work were examined among 271 metalworkers exposed to MWF and 24 metal workers not exposed to MWF at the same factory. At the same time, air levels of potentially harmful substances (oil mist, morpholine, monoethanolamine, formaldehyde) generated from MWF was measured. Nasal lavage fluid was collected from 13 workers and 15 controls and protein profiles were determined by a proteomic approach.
Airway symptoms were reported in 39% of the workers exposed to MWF although the measured levels of MWF substances in the work place air were low. Highest prevalence was found among workers handling the MWF machines but also those working in the same hall were affected. Improvement of the ventilation to reduce MWF exposure lowered the prevalence of airway problems. Protein profiling showed significantly higher levels of S100-A9 and lower levels of SPLUNC1, cystatin SN, Ig J and β2-microglobulin among workers with airway symptoms.
This study confirms that upper airway symptoms among metal workers are a common problem and despite low levels of MWF-generated substances, effects on airway immune proteins are found. Further studies to clarify the role of specific MWF components in connection to airway inflammation and the identified biological markers are warranted.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24391738</pmid><doi>10.1371/journal.pone.0083089</doi><tpages>e83089</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2013-12, Vol.8 (12), p.e83089 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1473341956 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; Free Full-Text Journals in Chemistry |
| subjects | Adult Air Pollutants, Occupational - adverse effects Air Pollutants, Occupational - analysis beta 2-Microglobulin - analysis Biological markers Biology Biomarkers Biomarkers - analysis Calgranulin B - analysis Case-Control Studies Councils Cross-Sectional Studies Cystatins Environmental health Ethanolamines Exposure Factories Female Fluids Formaldehyde Glycoproteins - analysis Health aspects Health sciences Humans Immunoglobulin J-Chains - analysis Immunoglobulins Inhalation Exposure Irritants - adverse effects Irritants - analysis Irritation Machinery Male Medicine Membranes Metallurgy Metalworking fluids Metalworking industry Middle Aged Mist Monoethanolamine (MEA) Morpholine Nasal Lavage Fluid - chemistry Neutrophils Nitric Oxide - analysis Occupational exposure Occupational Exposure - adverse effects Occupational Exposure - prevention & control Occupational health Oil mist Otolaryngology Personnel management Phosphoproteins - analysis Proteins Proteomics Questionnaires Respiratory tract Respiratory tract diseases Salivary Cystatins - analysis Trends Tumor Necrosis Factor-alpha - biosynthesis Ventilation VOCs Volatile organic compounds Work environment |
| title | Airway symptoms and biological markers in nasal lavage fluid in subjects exposed to metalworking fluids |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T03%3A25%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Airway%20symptoms%20and%20biological%20markers%20in%20nasal%20lavage%20fluid%20in%20subjects%20exposed%20to%20metalworking%20fluids&rft.jtitle=PloS%20one&rft.au=Fornander,%20Louise&rft.date=2013-12-31&rft.volume=8&rft.issue=12&rft.spage=e83089&rft.pages=e83089-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0083089&rft_dat=%3Cgale_plos_%3EA477926930%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1473341956&rft_id=info:pmid/24391738&rft_galeid=A477926930&rft_doaj_id=oai_doaj_org_article_46867b286c5c4e29acd5b3ea13ecea5a&rfr_iscdi=true |