Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule

It was recently proposed that UDP-galactose:ceramide galactosyltransferase (UGT8), enzyme responsible for synthesis of galactosylceramide (GalCer), is a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. To further reve...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e84191
Hauptverfasser:	Owczarek, Tomasz B, Suchanski, Jarosław, Pula, Bartosz, Kmiecik, Alicja M, Chadalski, Marek, Jethon, Aleksandra, Dziegiel, Piotr, Ugorski, Maciej
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Biochemistry Biology Biomarkers, Tumor - metabolism Brain cancer Breast cancer Breast Neoplasms - physiopathology Cancer Cancer cells Cancer metastasis Cancer therapies Cell Line, Tumor Ceramide Colonies Doxorubicin Doxorubicin - pharmacology Drug resistance Embryology Enzymes Female Galactose Galactosylceramide Galactosylceramides - metabolism Ganglioside Galactosyltransferase - metabolism Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Histology Humans Immunohistochemistry Immunology Ionizing radiation Laboratories Life sciences Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - secondary Medicine Metabolism Metabolites Metastases Metastasis Mice mRNA Ovarian cancer Pharmacology RNA RNA, Small Interfering - metabolism Rodent control Stress response Synthesis Toxicology Transplantation Tumor cells Tumorigenicity Tumors Veterinary medicine
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