Formation of spatially discordant alternans due to fluctuations and diffusion of calcium

Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where different regions of cardiac tissue exhibit an alternating sequence of APD that are out-of-phase. SDA is arrhythmogenic since it can induce spatial heterogeneity of refractoriness, which can cause wavebreak...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e85365-e85365
Hauptverfasser:	Sato, Daisuke, Bers, Donald M, Shiferaw, Yohannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials Calcium Calcium (intracellular) Calcium - metabolism Cardiac arrhythmia Cardiac muscle Conduction Cycles Diffusion Electric potential Fluctuations Glucans - biosynthesis Heart Heart diseases Models, Cardiovascular Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Ordinary differential equations Partial differential equations Reentry Restitution Rodents Sarcomeres - metabolism Sarcoplasmic reticulum Spatial heterogeneity Spatio-Temporal Analysis Stability Thermal resistance Voltage
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