Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis

Lupus nephritis is a cause of significant morbidity in systemic lupus erythematosus (SLE) and its genetic background has not been completely clarified. The aim of this investigation was to analyze single nucleotide polymorphisms (SNPs) for association with lupus nephritis, its severe form proliferat...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e84450-e84450
Hauptverfasser:	Bolin, Karin, Sandling, Johanna K, Zickert, Agneta, Jönsen, Andreas, Sjöwall, Christopher, Svenungsson, Elisabet, Bengtsson, Anders A, Eloranta, Maija-Leena, Rönnblom, Lars, Syvänen, Ann-Christine, Gunnarsson, Iva, Nordmark, Gunnel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Arthritis Autoimmune diseases Biology Biopsy Blood & organ donations Case-Control Studies Chromosomes Chronic conditions Clinical Medicine Consent Ethics Female Gangrene Genes Genetic aspects Genetic diversity Genetic Predisposition to Disease Genome-Wide Association Study Genomes Histocompatibility antigen HLA Histopathology Hospitals Humans IRAK protein Kidney diseases Kidney failure Kidneys Klinisk medicin Laboratories Lupus Lupus nephritis Lupus Nephritis - complications Lupus Nephritis - genetics Lymphoma Male Medical and Health Sciences MEDICIN Medicin och hälsovetenskap MEDICINE Meta-analysis Morbidity Mutation Nephritis Patients Polymorphism Polymorphism, Single Nucleotide Population Proliferative kidney disease Proteins Renal insufficiency Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - genetics Reumatologi och inflammation Rheumatology Rheumatology and Autoimmunity Science Severity of Illness Index Single nucleotide polymorphisms Single-nucleotide polymorphism Stat4 protein STAT4 Transcription Factor - genetics Studies Systemic lupus erythematosus Tumor necrosis factor-TNF White people
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