EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells

Epstein-Barr virus induced receptor 2 (EBI2), a Gαi-coupled G protein-coupled receptor, is a chemotactic receptor for B, T and dendritic cells (DC). Genetic studies have also implicated EBI2 as a regulator of an interferon regulatory factor 7 (IRF7)-driven inflammatory network (IDIN) associated with...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e83457-e83457
Hauptverfasser:	Chiang, Eugene Y, Johnston, Robert J, Grogan, Jane L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Autoimmune diseases Biology CD11b antigen Cell activation Chemotaxis - drug effects Chemotaxis - genetics Chemotaxis - immunology Cytokines Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Down-regulation Epstein-Barr virus Female Gene Expression Immune system Immunology Inflammation Interferon Interferon regulatory factor Interferon regulatory factor 7 Interferon Regulatory Factor-7 - metabolism Interferon Type I - metabolism Laboratory animals Leukocyte migration Ligands Lupus Lymphocytes Lymphocytes B Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - metabolism Lymphocytic choriomeningitis virus - immunology Mice Mice, Knockout Myeloid cells Myeloid Cells - immunology Myeloid Cells - metabolism Nucleic acids Peritoneal Cavity Peritoneum Pertussis Toxin - administration & dosage Proteins Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Rodents Signal Transduction Spleen Spleen - immunology Spleen - metabolism T cell receptors Toll-Like Receptors - metabolism Transcription factors Viral infections Viruses
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