Extracellular acidosis stimulates NHE2 expression through activation of transcription factor Egr-1 in the intestinal epithelial cells

Na(+)/H(+) exchangers (NHEs) play important roles in regulating internal pH (pHi), cell volume and neutral Na(+) absorption in the human intestine. Earlier studies have shown that low extracellular pH (pHe) and metabolic acidosis increases the expression and function of NHE1-3 genes. However, transc...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e82023-e82023
Hauptverfasser:	Muthusamy, Saminathan, Cheng, Ming, Jeong, Jong-Jin, Kumar, Anoop, Dudeja, Pradeep K, Malakooti, Jaleh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Acidosis - metabolism Acids Base Sequence Cell Line Cell Nucleus - metabolism Cell size Chloride Comparative analysis Early Growth Response Protein 1 - metabolism EGR-1 protein Enterocytes - metabolism Epithelial cells Extracellular Space - metabolism Gastroenterology Gene expression Gene Expression Regulation Genetic aspects Hepatology Homeostasis Humans Hydrogen ions Hydrogen-Ion Concentration Immunofluorescence Intestine Localization Medicine Metabolic acidosis Metabolism Microscopy Molecular modelling Molecular Sequence Data Na+/H+-exchanging ATPase pH effects Plasmids Polymerase chain reaction Promoter Regions, Genetic - genetics Protein Binding Protein Transport Proteins Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents siRNA Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - metabolism Sp1 protein Transcription activation Transcription factors Transcription, Genetic Vascular endothelial growth factor
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