Role of electrical activity in horizontal axon growth in the developing cortex: a time-lapse study using optogenetic stimulation

During development, layer 2/3 neurons in the neocortex extend their axons horizontally, within the same layers, and stop growing at appropriate locations to form branches and synaptic connections. Firing and synaptic activity are thought to be involved in this process, but how neuronal activity regu...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e82954
Hauptverfasser:	Malyshevskaya, Olga, Shiraishi, Yoshihiro, Kimura, Fumitaka, Yamamoto, Nobuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Animals, Newborn Axonogenesis Axons Axons - drug effects Axons - metabolism Axons - ultrastructure Biology Brain slice preparation Channelrhodopsins Confocal microscopy Cortex Electroporation Firing Firing pattern Gene Expression Growth Laboratories Light Luminescent Proteins - genetics Luminescent Proteins - metabolism Mammals Microscopy Morphology Motility Neurobiology Neurons Neurosciences Optogenetics Patch-Clamp Techniques Photic Stimulation Plasmids Rats Stimulation Synapses Tetrodotoxin Tetrodotoxin - pharmacology Time-Lapse Imaging Tissue Culture Techniques Visual Cortex - cytology Visual Cortex - drug effects Visual Cortex - growth & development Visual Cortex - metabolism
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