Deficiency of MIWI2 (Piwil4) induces mouse erythroleukemia cell differentiation, but has no effect on hematopoiesis in vivo

Piwi proteins and their small non-coding RNA partners are involved in the maintenance of stem cell character and genome integrity in the male germ cells of mammals. MIWI2, one of the mouse Piwi-like proteins, is expressed in the prepachytene phase of spermatogenesis during the period of de novo meth...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e82573-e82573
Hauptverfasser:	Jacobs, James E, Wagner, Mark, Dhahbi, Joseph, Boffelli, Dario, Martin, David I K
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acids Aging - pathology Animal tissues Animals Argonaute Proteins - deficiency Argonaute Proteins - metabolism Blood Cells - metabolism Cell cycle Cell Differentiation Cell Line, Tumor Cell self-renewal Children & youth Defects Differentiation (biology) DNA methylation Drosophila Erythroleukemia Gene Knockdown Techniques Genes Genomes Genomics Germ cells Hematopoiesis Hematopoietic stem cells Hemoglobins - metabolism House mouse Insects Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - pathology Life span Meiosis Methylation Mice Mice, Inbred C57BL mRNA Non-coding RNA Organ Specificity - genetics Progenitor cells Proteins Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - metabolism Rodents Sequence Analysis, RNA Spermatogenesis Spleen - metabolism Statistical analysis Stem cells Studies Whole-Body Irradiation
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