Sleep disorders in Parkinson's disease: clinical features, iron metabolism and related mechanism

To investigate clinical features, iron metabolism and neuroinflammation in Parkinson's disease (PD) patients with sleep disorders (SD). 211 PD patients were evaluated by Pittsburgh Sleep Quality Index (PSQI) and a body of scales for motor symptoms and non-motor symptoms. 94 blood and 38 cerebra...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e82924
Hauptverfasser:	Yu, Shu-Yang, Sun, Li, Liu, Zhuo, Huang, Xi-Yan, Zuo, Li-Jun, Cao, Chen-Jie, Zhang, Wei, Wang, Xiao-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Autonomic nervous system Bioengineering Brain Brain research Cerebrospinal fluid Cytokines Deposition Depression - blood Depression - cerebrospinal fluid Depression - complications Depression - physiopathology Development and progression Dinoprostone - cerebrospinal fluid Disease Disorders Dopamine Drug development Engineering research Enzymes Fatigue Fatigue - blood Fatigue - cerebrospinal fluid Fatigue - complications Fatigue - physiopathology Female Hospitals Humans Inflammation Iron Iron - blood Lactoferrin Lactoferrin - cerebrospinal fluid Leg Male Medical research Mental depression Metabolism Microglia Middle Aged Movement disorders Neurodegenerative diseases Neurology Neurotoxicity Nitric oxide Parkinson Disease - blood Parkinson Disease - cerebrospinal fluid Parkinson Disease - complications Parkinson Disease - physiopathology Parkinson's disease Pathology Patients Physiological aspects Prostaglandin E2 Proteins Restless legs syndrome Restless Legs Syndrome - blood Restless Legs Syndrome - cerebrospinal fluid Restless Legs Syndrome - complications Restless Legs Syndrome - physiopathology Rheumatoid arthritis Severity of Illness Index Sleep Sleep disorders Sleep Initiation and Maintenance Disorders - blood Sleep Initiation and Maintenance Disorders - cerebrospinal fluid Sleep Initiation and Maintenance Disorders - complications Sleep Initiation and Maintenance Disorders - physiopathology Transferrin Transferrin - metabolism Transferrins Tumor necrosis factor Tumor Necrosis Factor-alpha - cerebrospinal fluid Tumor necrosis factor-TNF
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