Intestinal upregulation of melanin-concentrating hormone in TNBS-induced enterocolitis in adult zebrafish

Melanin-concentrating hormone (MCH), an evolutionarily conserved appetite-regulating neuropeptide, has been recently implicated in the pathogenesis of inflammatory bowel disease (IBD). Expression of MCH is upregulated in inflamed intestinal mucosa in humans with colitis and MCH-deficient mice treate...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e83194
Hauptverfasser:	Geiger, Brenda M, Gras-Miralles, Beatriz, Ziogas, Dimitrios C, Karagiannis, Apostolos K A, Zhen, Aileen, Fraenkel, Paula, Kokkotou, Efi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Rectal Amino acids Animal models Animals Antibiotics Appetite Cell Movement Colitis Comparative analysis Cytokines Cytokines - genetics Cytokines - metabolism Danio rerio Disease Models, Animal Enterocolitis Enterocolitis - chemically induced Enterocolitis - genetics Enterocolitis - mortality Enterocolitis - pathology Fish Fish Proteins - genetics Fish Proteins - metabolism Fishes Gastroenterology Gastrointestinal diseases Gene Expression Regulation Hematology Hormones Humans Hypothalamic Hormones - genetics Hypothalamic Hormones - metabolism Infiltration Inflammation Inflammatory bowel disease Inflammatory bowel diseases Intestinal Mucosa - metabolism Intestine Intestines - microbiology Intestines - pathology Larvae Male Mammals Medical schools Melanin Melanin-concentrating hormone Melanins - genetics Melanins - metabolism Microbiota Microbiota - drug effects Mucosa Neuropeptides Pathogenesis Peroxidase Peroxidase - genetics Peroxidase - metabolism Pituitary Hormones - genetics Pituitary Hormones - metabolism Receptors, Pituitary Hormone - genetics Receptors, Pituitary Hormone - metabolism Rodents Studies Sulfonic acid Survival Survival Analysis Transcription Trinitrobenzenesulfonic Acid Up-regulation Vancomycin Vancomycin - pharmacology Wildlife conservation Zebrafish
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