GNB3, eNOS, and mitochondrial DNA polymorphisms correlate to natural longevity in a Xinjiang Uygur population
In centenarian populations, application of the positive biology approach (examination of positive phenotypes in aging) has revealed that mitochondrial DNA (mtDNA) mutation accumulation may be linked to human longevity; however, the role of guanine nucleotide-binding protein (G protein) abnormalities...
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| creator | Nijiati, Muyesai Saidaming, Abulajiang Qiao, Jun Cheng, Zuheng Qiu, Changchun Sun, Yujing |
| description | In centenarian populations, application of the positive biology approach (examination of positive phenotypes in aging) has revealed that mitochondrial DNA (mtDNA) mutation accumulation may be linked to human longevity; however, the role of guanine nucleotide-binding protein (G protein) abnormalities modulated by G-protein beta-3 (GNB3) and nitrate (NO2) production associated with endothelial nitric oxide synthase (eNOS), commonly appearing in age-related diseases, remains undetermined.
The association between the mtDNA 5178A/C, mtDNA 10398A/G, GNB3 C825T, and eNOS polymorphisms and longevity in a Uygur population (Xinjiang region, China) were investigated.
A total of 275 experimental subjects aged ≥ 100 or with 4 generations currently living were screened for inclusion in the centenarian (>100 years) and nonagenarian groups (90-100 years), and 112 65-70 year old control subjects were selected. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine mtDNA 5178A/C, mtDNA 10398A/G, GNB3 C825T, and eNOS. Associations between polymorphic loci, genotypes, and longevity were analyzed.
165 included subjects (M∶F = 107∶58; mean age = 97 ± 3 years; mean age 100-113 years) were assigned to the centenarian (M∶F = 46/19; n = 65) and nonagenarian groups (M∶F = 61/39; n = 100). Associations between mtDNA C5178A and A10398G polymorphisms with longevity in the centenarian group with mtDNA genotype frequencies 5178A and 10398G were 66.79% and 36.8%.
Applying the overwhelming longevity observed in Uygur populations, these findings demonstrate that mtDNA 5178A/C and 10398A/G, GNB3 C825T, and eNOS polymorphisms are useful as a genetic basis for longevity. |
| doi_str_mv | 10.1371/journal.pone.0081806 |
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The association between the mtDNA 5178A/C, mtDNA 10398A/G, GNB3 C825T, and eNOS polymorphisms and longevity in a Uygur population (Xinjiang region, China) were investigated.
A total of 275 experimental subjects aged ≥ 100 or with 4 generations currently living were screened for inclusion in the centenarian (>100 years) and nonagenarian groups (90-100 years), and 112 65-70 year old control subjects were selected. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine mtDNA 5178A/C, mtDNA 10398A/G, GNB3 C825T, and eNOS. Associations between polymorphic loci, genotypes, and longevity were analyzed.
165 included subjects (M∶F = 107∶58; mean age = 97 ± 3 years; mean age 100-113 years) were assigned to the centenarian (M∶F = 46/19; n = 65) and nonagenarian groups (M∶F = 61/39; n = 100). Associations between mtDNA C5178A and A10398G polymorphisms with longevity in the centenarian group with mtDNA genotype frequencies 5178A and 10398G were 66.79% and 36.8%.
Applying the overwhelming longevity observed in Uygur populations, these findings demonstrate that mtDNA 5178A/C and 10398A/G, GNB3 C825T, and eNOS polymorphisms are useful as a genetic basis for longevity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0081806</identifier><identifier>PMID: 24376503</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Age ; Aged, 80 and over ; Aging ; Aging (natural) ; Alleles ; China ; Demography ; Deoxyribonucleic acid ; DNA ; DNA, Mitochondrial - genetics ; Endothelium ; Ethnic Groups - genetics ; Female ; G proteins ; Gene Frequency ; Gene polymorphism ; Genetic aspects ; Genetic Loci ; Genetic polymorphisms ; Genetics, Population ; Genotypes ; Guanine ; Guanine nucleotide-binding protein ; Haplotypes - genetics ; Heterotrimeric GTP-Binding Proteins - genetics ; Humans ; Longevity ; Longevity - genetics ; Male ; Mitochondrial DNA ; Mortality ; Mutation ; Nitric oxide ; Nitric Oxide Synthase Type III - genetics ; Nitric-oxide synthase ; Nitrogen dioxide ; Nonagenarian ; Polymerase chain reaction ; Polymorphism ; Polymorphism, Genetic ; Populations ; Protein binding ; Purines ; Restriction fragment length polymorphism ; Rodents ; Uighurs</subject><ispartof>PloS one, 2013-12, Vol.8 (12), p.e81806-e81806</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Nijiati et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Nijiati et al 2013 Nijiati et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6076-a818e97fb02f14f6db2e00a8e346e31930da11ead0063297421316e3e1ab404c3</citedby><cites>FETCH-LOGICAL-c6076-a818e97fb02f14f6db2e00a8e346e31930da11ead0063297421316e3e1ab404c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869651/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869651/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24376503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Virolle, Marie-Joelle</contributor><creatorcontrib>Nijiati, Muyesai</creatorcontrib><creatorcontrib>Saidaming, Abulajiang</creatorcontrib><creatorcontrib>Qiao, Jun</creatorcontrib><creatorcontrib>Cheng, Zuheng</creatorcontrib><creatorcontrib>Qiu, Changchun</creatorcontrib><creatorcontrib>Sun, Yujing</creatorcontrib><title>GNB3, eNOS, and mitochondrial DNA polymorphisms correlate to natural longevity in a Xinjiang Uygur population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In centenarian populations, application of the positive biology approach (examination of positive phenotypes in aging) has revealed that mitochondrial DNA (mtDNA) mutation accumulation may be linked to human longevity; however, the role of guanine nucleotide-binding protein (G protein) abnormalities modulated by G-protein beta-3 (GNB3) and nitrate (NO2) production associated with endothelial nitric oxide synthase (eNOS), commonly appearing in age-related diseases, remains undetermined.
The association between the mtDNA 5178A/C, mtDNA 10398A/G, GNB3 C825T, and eNOS polymorphisms and longevity in a Uygur population (Xinjiang region, China) were investigated.
A total of 275 experimental subjects aged ≥ 100 or with 4 generations currently living were screened for inclusion in the centenarian (>100 years) and nonagenarian groups (90-100 years), and 112 65-70 year old control subjects were selected. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine mtDNA 5178A/C, mtDNA 10398A/G, GNB3 C825T, and eNOS. Associations between polymorphic loci, genotypes, and longevity were analyzed.
165 included subjects (M∶F = 107∶58; mean age = 97 ± 3 years; mean age 100-113 years) were assigned to the centenarian (M∶F = 46/19; n = 65) and nonagenarian groups (M∶F = 61/39; n = 100). Associations between mtDNA C5178A and A10398G polymorphisms with longevity in the centenarian group with mtDNA genotype frequencies 5178A and 10398G were 66.79% and 36.8%.
Applying the overwhelming longevity observed in Uygur populations, these findings demonstrate that mtDNA 5178A/C and 10398A/G, GNB3 C825T, and eNOS polymorphisms are useful as a genetic basis for longevity.</description><subject>Abnormalities</subject><subject>Age</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging (natural)</subject><subject>Alleles</subject><subject>China</subject><subject>Demography</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Endothelium</subject><subject>Ethnic Groups - genetics</subject><subject>Female</subject><subject>G proteins</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic Loci</subject><subject>Genetic polymorphisms</subject><subject>Genetics, Population</subject><subject>Genotypes</subject><subject>Guanine</subject><subject>Guanine nucleotide-binding protein</subject><subject>Haplotypes - genetics</subject><subject>Heterotrimeric GTP-Binding Proteins - genetics</subject><subject>Humans</subject><subject>Longevity</subject><subject>Longevity - genetics</subject><subject>Male</subject><subject>Mitochondrial DNA</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Nitric-oxide synthase</subject><subject>Nitrogen dioxide</subject><subject>Nonagenarian</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Populations</subject><subject>Protein binding</subject><subject>Purines</subject><subject>Restriction fragment length polymorphism</subject><subject>Rodents</subject><subject>Uighurs</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYqPwDxBYmoRAWou_6iQ3SGXAqDS1EmOIO8txnNSVYwc7mei_x6XZ1KBdoFw4sp_znnNe-yTJSwRniKTo_db13goza51VMwgzlEH2KDlFOcFThiF5fPR_kjwLYQvhnGSMPU1OMCUpm0NymjSXq4_kHKjV-vocCFuCRndObpwtvRYGfFotQOvMrnG-3ejQBCCd98qIToHOASu63kfMOFurW93tgLZAgJ_abrWwNbjZ1b2PAm0fI7Szz5MnlTBBvRjWSXLz5fP3i6_Tq_Xl8mJxNZUMpmwqYjMqT6sC4grRipUFVhCKTBHKFIldwVIgpEQJISM4TylGBMUThURBIZVkkrw-6LbGBT44FTiiaTQK54xEYnkgSie2vPW6EX7HndD874bzNRe-09IonjJK5wWpJFKQCiGKPNaIZcZwLBJHKyfJhyFbXzSqlMp20ZSR6PjE6g2v3S2Pt5GzOYoCbwcB7371KnS80UEqY4RVrt_XHVOSLGdZRM_-QR_ubqBqERvQtnIxr9yL8gVNMwwpxixSsweo-JWq0TI-q0rH_VHAu1FAZDr1u6tFHwJfXn_7f3b9Y8y-OWI3SphuE5zp908mjEF6AKV3IXhV3ZuMIN9PxZ0bfD8VfJiKGPbq-ILug-7GgPwBQK4FxQ</recordid><startdate>20131220</startdate><enddate>20131220</enddate><creator>Nijiati, Muyesai</creator><creator>Saidaming, Abulajiang</creator><creator>Qiao, Jun</creator><creator>Cheng, Zuheng</creator><creator>Qiu, Changchun</creator><creator>Sun, Yujing</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131220</creationdate><title>GNB3, eNOS, and mitochondrial DNA polymorphisms correlate to natural longevity in a Xinjiang Uygur population</title><author>Nijiati, Muyesai ; Saidaming, Abulajiang ; Qiao, Jun ; Cheng, Zuheng ; Qiu, Changchun ; Sun, Yujing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6076-a818e97fb02f14f6db2e00a8e346e31930da11ead0063297421316e3e1ab404c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abnormalities</topic><topic>Age</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging (natural)</topic><topic>Alleles</topic><topic>China</topic><topic>Demography</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA, Mitochondrial - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nijiati, Muyesai</au><au>Saidaming, Abulajiang</au><au>Qiao, Jun</au><au>Cheng, Zuheng</au><au>Qiu, Changchun</au><au>Sun, Yujing</au><au>Virolle, Marie-Joelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GNB3, eNOS, and mitochondrial DNA polymorphisms correlate to natural longevity in a Xinjiang Uygur population</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-12-20</date><risdate>2013</risdate><volume>8</volume><issue>12</issue><spage>e81806</spage><epage>e81806</epage><pages>e81806-e81806</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In centenarian populations, application of the positive biology approach (examination of positive phenotypes in aging) has revealed that mitochondrial DNA (mtDNA) mutation accumulation may be linked to human longevity; however, the role of guanine nucleotide-binding protein (G protein) abnormalities modulated by G-protein beta-3 (GNB3) and nitrate (NO2) production associated with endothelial nitric oxide synthase (eNOS), commonly appearing in age-related diseases, remains undetermined.
The association between the mtDNA 5178A/C, mtDNA 10398A/G, GNB3 C825T, and eNOS polymorphisms and longevity in a Uygur population (Xinjiang region, China) were investigated.
A total of 275 experimental subjects aged ≥ 100 or with 4 generations currently living were screened for inclusion in the centenarian (>100 years) and nonagenarian groups (90-100 years), and 112 65-70 year old control subjects were selected. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine mtDNA 5178A/C, mtDNA 10398A/G, GNB3 C825T, and eNOS. Associations between polymorphic loci, genotypes, and longevity were analyzed.
165 included subjects (M∶F = 107∶58; mean age = 97 ± 3 years; mean age 100-113 years) were assigned to the centenarian (M∶F = 46/19; n = 65) and nonagenarian groups (M∶F = 61/39; n = 100). Associations between mtDNA C5178A and A10398G polymorphisms with longevity in the centenarian group with mtDNA genotype frequencies 5178A and 10398G were 66.79% and 36.8%.
Applying the overwhelming longevity observed in Uygur populations, these findings demonstrate that mtDNA 5178A/C and 10398A/G, GNB3 C825T, and eNOS polymorphisms are useful as a genetic basis for longevity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24376503</pmid><doi>10.1371/journal.pone.0081806</doi><tpages>e81806</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2013-12, Vol.8 (12), p.e81806-e81806 |
| issn | 1932-6203 1932-6203 |
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| recordid | cdi_plos_journals_1470082963 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Age Aged, 80 and over Aging Aging (natural) Alleles China Demography Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Endothelium Ethnic Groups - genetics Female G proteins Gene Frequency Gene polymorphism Genetic aspects Genetic Loci Genetic polymorphisms Genetics, Population Genotypes Guanine Guanine nucleotide-binding protein Haplotypes - genetics Heterotrimeric GTP-Binding Proteins - genetics Humans Longevity Longevity - genetics Male Mitochondrial DNA Mortality Mutation Nitric oxide Nitric Oxide Synthase Type III - genetics Nitric-oxide synthase Nitrogen dioxide Nonagenarian Polymerase chain reaction Polymorphism Polymorphism, Genetic Populations Protein binding Purines Restriction fragment length polymorphism Rodents Uighurs |
| title | GNB3, eNOS, and mitochondrial DNA polymorphisms correlate to natural longevity in a Xinjiang Uygur population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T23%3A05%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=GNB3,%20eNOS,%20and%20mitochondrial%20DNA%20polymorphisms%20correlate%20to%20natural%20longevity%20in%20a%20Xinjiang%20Uygur%20population&rft.jtitle=PloS%20one&rft.au=Nijiati,%20Muyesai&rft.date=2013-12-20&rft.volume=8&rft.issue=12&rft.spage=e81806&rft.epage=e81806&rft.pages=e81806-e81806&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0081806&rft_dat=%3Cgale_plos_%3EA478204226%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1470082963&rft_id=info:pmid/24376503&rft_galeid=A478204226&rft_doaj_id=oai_doaj_org_article_76445b3fc1e04aaab90762c8628e9224&rfr_iscdi=true |