Norcantharidin induced DU145 cell apoptosis through ROS-mediated mitochondrial dysfunction and energy depletion

Norcantharidin (NCTD), a demethylated analog of cantharidin derived from blister beetles, has attracted considerable attentions in recent years due to their definitely toxic properties and the noteworthy advantages in stimulating bone marrow and increasing the peripheral leukocytes. Hence, it is wor...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e84610
Hauptverfasser:	Shen, Bo, He, Pei-Jie, Shao, Chun-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism AMP AMP-Activated Protein Kinases Anticancer properties Antigens Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects ATP Beetles Bisbenzimidazole Blistering Blotting, Western Bone marrow Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cancer therapies Care and treatment Cell culture Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cytochrome Cytochrome c Cytochromes c - metabolism Deoxyribonucleic acid Depletion DNA DNA damage Dose-Response Relationship, Drug Flow Cytometry Gallbladder Humans In Situ Nick-End Labeling Kinases Leukocytes Male Medical prognosis Membrane potential Membrane Potential, Mitochondrial - drug effects Micronucleus Tests Mitochondria Mitochondria - drug effects Norcantharidin Phosphatase Polyethylene glycol Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - metabolism Prostate cancer Prostatic Neoplasms - drug therapy Protein kinase Proteins Reactive Oxygen Species - metabolism Superoxide Dismutase - metabolism
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