Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters

Cervical cancer cells exhibit an increased requirement for ubiquitin-dependent protein degradation associated with an elevated metabolic turnover rate. Ubiquitin, which is a small, highly conserved protein expressed in all eukaryotic cells, can be covalently linked to certain target proteins to mark...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e84457
Hauptverfasser:	Tian, Yuan, Ding, Wencheng, Wang, Yingying, Ji, Teng, Sun, Shujuan, Mo, Qingqing, Chen, Pingbo, Fang, Yong, Liu, Jia, Wang, Beibei, Zhou, Jianfeng, Ma, Ding, Wu, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biodegradation Biology Biomarkers Breast cancer Cancer Cancer therapies Cell cycle Cell proliferation Cell Transformation, Neoplastic - drug effects Cervical cancer Cervix Chemoresistance Chemotherapy Cosmetics industry Degradation Disease Drug resistance Drug Resistance, Neoplasm - drug effects Female Gene Expression Regulation, Neoplastic - drug effects Gene Silencing Genes HeLa Cells Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Hospitals Humans Hydroxamic Acids - pharmacology Hypotheses Malignancy Mice Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oct-4 protein Pathology Proteasomes Proteins Proteolysis RNA, Small Interfering - genetics Science Selectivity Spheroids, Cellular - drug effects Spheroids, Cellular - pathology Squamous cell carcinoma Stem cells Trichostatin A Tumors Turnover rate Ubiquitin Ubiquitin - deficiency Ubiquitin - genetics Ubiquitin - metabolism Up-Regulation - drug effects Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Vaccines Western blotting Xenografts
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