Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin

Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) lead to significant cardiovascular morbidity and mortality worldwide. Mutations in the genes encoding the sarcomere, the force-generating unit in the cardiomyocyte, cause familial forms of both HCM and DCM. This study examines two HC...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e83403-e83403
Hauptverfasser:	Sommese, Ruth F, Nag, Suman, Sutton, Shirley, Miller, Susan M, Spudich, James A, Ruppel, Kathleen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Actomyosin Actomyosin - metabolism Adenosine diphosphate Adult Biochemistry Calcium Calcium - metabolism Calcium-binding protein Cardiomyocytes Cardiomyopathies - genetics Cardiomyopathies - metabolism Cardiomyopathies - pathology Cardiomyopathy Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - pathology Cardiomyopathy, Hypertrophic - genetics Cardiomyopathy, Hypertrophic - metabolism Cardiomyopathy, Hypertrophic - pathology Cardiovascular diseases Dilated cardiomyopathy Heart Heart diseases Humans Isoforms Kinetics Medicine Models, Molecular Morbidity Mutation Myosin Myosin Subfragments - metabolism Protein Structure, Secondary Proteins Sensitivity Studies Tropomyosin - metabolism Troponin Troponin T Troponin T - chemistry Troponin T - genetics Troponin T - metabolism Ventricular Myosins - metabolism
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