Prdm6 is essential for cardiovascular development in vivo

Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Co...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81833
Hauptverfasser:	Gewies, Andreas, Castineiras-Vilarino, Mercedes, Ferch, Uta, Jährling, Nina, Heinrich, Katja, Hoeckendorf, Ulrike, Przemeck, Gerhard K H, Munding, Matthias, Groß, Olaf, Schroeder, Timm, Horsch, Marion, Karran, E Loraine, Majid, Aneela, Antonowicz, Stefan, Beckers, Johannes, Hrabé de Angelis, Martin, Dodt, Hans-Ulrich, Peschel, Christian, Förster, Irmgard, Dyer, Martin J S, Ruland, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Angiogenesis Animals Base Sequence Blotting, Northern Blotting, Southern Body Patterning Brain research Cancer Cardiovascular system Cardiovascular System - embryology Cell cycle Cell Differentiation Cell lineage Cell Proliferation Clonal deletion Consortia Defects DNA Primers Embryo cells Embryogenesis Embryonic development Embryonic growth stage Embryonic stem cells Embryos Environmental health Gene expression Genetics Hemorrhage Immune system Immunology Internal medicine Laboratories Lethality Lungs Medical research Medicine Mice Mice, Knockout Muscle, Smooth - cytology Muscles Neovascularization, Physiologic Neurosciences Oligonucleotide Array Sequence Analysis Pattern formation Physiological effects Physiology Polymerase Chain Reaction Proteins Repressor Proteins - genetics Repressor Proteins - physiology Smooth muscle Stem cell transplantation Stem cells Toxicology Vascular system
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