Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues
Obesity is a world-wide epidemic disease that correlates closely with type 2 diabetes and cardiovascular diseases. Obesity-induced chronic adipose tissue inflammation is now considered as a critical contributor to the above complications. Momordica charantia (bitter melon, BM) is a traditional Chine...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-12, Vol.8 (12), p.e84075-e84075 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e84075 |
|---|---|
| container_issue | 12 |
| container_start_page | e84075 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Bao, Bin Chen, Yan-Guang Zhang, Lei Na Xu, Yan Lin Wang, Xin Liu, Jian Qu, Wei |
| description | Obesity is a world-wide epidemic disease that correlates closely with type 2 diabetes and cardiovascular diseases. Obesity-induced chronic adipose tissue inflammation is now considered as a critical contributor to the above complications. Momordica charantia (bitter melon, BM) is a traditional Chinese food and well known for its function of reducing body weight gain and insulin resistance. However, it is unclear whether BM could alleviate adipose tissue inflammation caused by obesity. In this study, C57BL/6 mice were fed high fat diet (HFD) with or without BM for 12 weeks. BM-contained diets ameliorated HFD-induced obesity and insulin resistance. Histological and real-time PCR analysis demonstrated BM not only reduced macrophage infiltration into epididymal adipose tissues (EAT) and brown adipose tissues (BAT). Flow cytometry show that BM could modify the M1/M2 phenotype ratio of macrophages in EAT. Further study showed that BM lowered mast cell recruitments in EAT, and depressed pro-inflammatory cytokine monocyte chemotactic protein-1 (MCP-1) expression in EAT and BAT as well as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) expression in EAT. Finally, ELISA analysis showed BM-contained diets also normalized serum levels of the cytokines. In summary, in concert with ameliorated insulin resistance and fat deposition, BM reduced adipose tissue inflammation in diet-induced obese (DIO) mice. |
| doi_str_mv | 10.1371/journal.pone.0084075 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1468886312</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478243025</galeid><doaj_id>oai_doaj_org_article_a802d0d8e03142d98b4c654e040d5307</doaj_id><sourcerecordid>A478243025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c659t-8e7f7f4215425812d70fbabb846081d9a4f1535c84943feb5c647cf03afe93d43</originalsourceid><addsrcrecordid>eNptUk1v1DAQjRCIlsI_QGCJSznsYsd24lwqlYqPSq24wNma2JNdL0m82F5g_w6_FIdNqxZVOTgev3kz8-YVxUtGl4zX7N3G78II_XLrR1xSqgSt5aPimDW8XFQl5Y_v_B8Vz2LcUCq5qqqnxVEpuFS8bI6LP9d-8ME6A8SsIcCYHJDT9y4lDOQaez--JQHtzmAkvsXo0n4BMXrjIKElA5jgt2tYIYFxusZEDPY9cWPn-hQgOT8SiOTXFMxnjvcwDJB82BOzT_67G5Hg723AGCesy3Drtj4iSS7GHcbnxZMO-ogv5vOk-Pbxw9eLz4urL58uL86vFqaSTVoorLu6EyWTopSKlbamXQttq0RFFbMNiI5JLo0SjeAdttJUojYd5dBhw63gJ8XrA--291HP8kbNRKWUqjgrM-LygLAeNnob3ABhrz04_S_gw0pDSM70qEHR0lKrkHImStuoVuQ2BVJBreS0zlxnc7VdO6A1OGa1-nuk919Gt9Yr_1NPK2TVRHA6EwT_I8uU9ODipD2M6HdT300uUzFJM_TNf9CHp5tRK8gD5EX5XNdMpPpc1Cp7hpYyo5YPoPJncXAmezHvHe8niENCdkqMAbvbGRnVk5NvmtGTk_Xs5Jz26q4-t0k31uV_AQoM830</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1468886312</pqid></control><display><type>article</type><title>Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Bao, Bin ; Chen, Yan-Guang ; Zhang, Lei ; Na Xu, Yan Lin ; Wang, Xin ; Liu, Jian ; Qu, Wei</creator><contributor>Fritz, Jörg Hermann</contributor><creatorcontrib>Bao, Bin ; Chen, Yan-Guang ; Zhang, Lei ; Na Xu, Yan Lin ; Wang, Xin ; Liu, Jian ; Qu, Wei ; Fritz, Jörg Hermann</creatorcontrib><description>Obesity is a world-wide epidemic disease that correlates closely with type 2 diabetes and cardiovascular diseases. Obesity-induced chronic adipose tissue inflammation is now considered as a critical contributor to the above complications. Momordica charantia (bitter melon, BM) is a traditional Chinese food and well known for its function of reducing body weight gain and insulin resistance. However, it is unclear whether BM could alleviate adipose tissue inflammation caused by obesity. In this study, C57BL/6 mice were fed high fat diet (HFD) with or without BM for 12 weeks. BM-contained diets ameliorated HFD-induced obesity and insulin resistance. Histological and real-time PCR analysis demonstrated BM not only reduced macrophage infiltration into epididymal adipose tissues (EAT) and brown adipose tissues (BAT). Flow cytometry show that BM could modify the M1/M2 phenotype ratio of macrophages in EAT. Further study showed that BM lowered mast cell recruitments in EAT, and depressed pro-inflammatory cytokine monocyte chemotactic protein-1 (MCP-1) expression in EAT and BAT as well as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) expression in EAT. Finally, ELISA analysis showed BM-contained diets also normalized serum levels of the cytokines. In summary, in concert with ameliorated insulin resistance and fat deposition, BM reduced adipose tissue inflammation in diet-induced obese (DIO) mice.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0084075</identifier><identifier>PMID: 24358329</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipose tissue ; Adipose Tissue - metabolism ; Adipose Tissue - pathology ; Adiposity ; Animal tissues ; Animals ; Body weight ; Body weight gain ; Cardiovascular diseases ; Complications ; Cytokines ; Cytokines - blood ; Cytokines - metabolism ; Cytometry ; Diabetes mellitus ; Diet ; Enzyme-linked immunosorbent assay ; Epidemics ; Flow cytometry ; Heart diseases ; High fat diet ; House mouse ; Infiltration ; Inflammation ; Inflammation Mediators - blood ; Inflammation Mediators - metabolism ; Insulin ; Insulin Resistance ; Interleukin 6 ; Kinases ; Macrophages ; Macrophages - metabolism ; Macrophages - pathology ; Male ; Mast Cells - metabolism ; Mast Cells - pathology ; Metastases ; Mice ; Momordica charantia ; Momordica charantia - chemistry ; Monocyte chemoattractant protein 1 ; Obesity ; Obesity - diet therapy ; Obesity - etiology ; Obesity - metabolism ; Phenotype ; Rodents ; Serum levels ; Traditional foods ; Tumor necrosis factor-α ; Type 2 diabetes ; Weight reduction</subject><ispartof>PloS one, 2013-12, Vol.8 (12), p.e84075-e84075</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Bao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Bao et al 2013 Bao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-8e7f7f4215425812d70fbabb846081d9a4f1535c84943feb5c647cf03afe93d43</citedby><cites>FETCH-LOGICAL-c659t-8e7f7f4215425812d70fbabb846081d9a4f1535c84943feb5c647cf03afe93d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866167/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866167/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24358329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fritz, Jörg Hermann</contributor><creatorcontrib>Bao, Bin</creatorcontrib><creatorcontrib>Chen, Yan-Guang</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Na Xu, Yan Lin</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Qu, Wei</creatorcontrib><title>Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Obesity is a world-wide epidemic disease that correlates closely with type 2 diabetes and cardiovascular diseases. Obesity-induced chronic adipose tissue inflammation is now considered as a critical contributor to the above complications. Momordica charantia (bitter melon, BM) is a traditional Chinese food and well known for its function of reducing body weight gain and insulin resistance. However, it is unclear whether BM could alleviate adipose tissue inflammation caused by obesity. In this study, C57BL/6 mice were fed high fat diet (HFD) with or without BM for 12 weeks. BM-contained diets ameliorated HFD-induced obesity and insulin resistance. Histological and real-time PCR analysis demonstrated BM not only reduced macrophage infiltration into epididymal adipose tissues (EAT) and brown adipose tissues (BAT). Flow cytometry show that BM could modify the M1/M2 phenotype ratio of macrophages in EAT. Further study showed that BM lowered mast cell recruitments in EAT, and depressed pro-inflammatory cytokine monocyte chemotactic protein-1 (MCP-1) expression in EAT and BAT as well as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) expression in EAT. Finally, ELISA analysis showed BM-contained diets also normalized serum levels of the cytokines. In summary, in concert with ameliorated insulin resistance and fat deposition, BM reduced adipose tissue inflammation in diet-induced obese (DIO) mice.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue - pathology</subject><subject>Adiposity</subject><subject>Animal tissues</subject><subject>Animals</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Cardiovascular diseases</subject><subject>Complications</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - metabolism</subject><subject>Cytometry</subject><subject>Diabetes mellitus</subject><subject>Diet</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epidemics</subject><subject>Flow cytometry</subject><subject>Heart diseases</subject><subject>High fat diet</subject><subject>House mouse</subject><subject>Infiltration</subject><subject>Inflammation</subject><subject>Inflammation Mediators - blood</subject><subject>Inflammation Mediators - metabolism</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Interleukin 6</subject><subject>Kinases</subject><subject>Macrophages</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - pathology</subject><subject>Male</subject><subject>Mast Cells - metabolism</subject><subject>Mast Cells - pathology</subject><subject>Metastases</subject><subject>Mice</subject><subject>Momordica charantia</subject><subject>Momordica charantia - chemistry</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Obesity</subject><subject>Obesity - diet therapy</subject><subject>Obesity - etiology</subject><subject>Obesity - metabolism</subject><subject>Phenotype</subject><subject>Rodents</subject><subject>Serum levels</subject><subject>Traditional foods</subject><subject>Tumor necrosis factor-α</subject><subject>Type 2 diabetes</subject><subject>Weight reduction</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAQjRCIlsI_QGCJSznsYsd24lwqlYqPSq24wNma2JNdL0m82F5g_w6_FIdNqxZVOTgev3kz8-YVxUtGl4zX7N3G78II_XLrR1xSqgSt5aPimDW8XFQl5Y_v_B8Vz2LcUCq5qqqnxVEpuFS8bI6LP9d-8ME6A8SsIcCYHJDT9y4lDOQaez--JQHtzmAkvsXo0n4BMXrjIKElA5jgt2tYIYFxusZEDPY9cWPn-hQgOT8SiOTXFMxnjvcwDJB82BOzT_67G5Hg723AGCesy3Drtj4iSS7GHcbnxZMO-ogv5vOk-Pbxw9eLz4urL58uL86vFqaSTVoorLu6EyWTopSKlbamXQttq0RFFbMNiI5JLo0SjeAdttJUojYd5dBhw63gJ8XrA--291HP8kbNRKWUqjgrM-LygLAeNnob3ABhrz04_S_gw0pDSM70qEHR0lKrkHImStuoVuQ2BVJBreS0zlxnc7VdO6A1OGa1-nuk919Gt9Yr_1NPK2TVRHA6EwT_I8uU9ODipD2M6HdT300uUzFJM_TNf9CHp5tRK8gD5EX5XNdMpPpc1Cp7hpYyo5YPoPJncXAmezHvHe8niENCdkqMAbvbGRnVk5NvmtGTk_Xs5Jz26q4-t0k31uV_AQoM830</recordid><startdate>20131217</startdate><enddate>20131217</enddate><creator>Bao, Bin</creator><creator>Chen, Yan-Guang</creator><creator>Zhang, Lei</creator><creator>Na Xu, Yan Lin</creator><creator>Wang, Xin</creator><creator>Liu, Jian</creator><creator>Qu, Wei</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131217</creationdate><title>Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues</title><author>Bao, Bin ; Chen, Yan-Guang ; Zhang, Lei ; Na Xu, Yan Lin ; Wang, Xin ; Liu, Jian ; Qu, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-8e7f7f4215425812d70fbabb846081d9a4f1535c84943feb5c647cf03afe93d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue - pathology</topic><topic>Adiposity</topic><topic>Animal tissues</topic><topic>Animals</topic><topic>Body weight</topic><topic>Body weight gain</topic><topic>Cardiovascular diseases</topic><topic>Complications</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - metabolism</topic><topic>Cytometry</topic><topic>Diabetes mellitus</topic><topic>Diet</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epidemics</topic><topic>Flow cytometry</topic><topic>Heart diseases</topic><topic>High fat diet</topic><topic>House mouse</topic><topic>Infiltration</topic><topic>Inflammation</topic><topic>Inflammation Mediators - blood</topic><topic>Inflammation Mediators - metabolism</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Interleukin 6</topic><topic>Kinases</topic><topic>Macrophages</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - pathology</topic><topic>Male</topic><topic>Mast Cells - metabolism</topic><topic>Mast Cells - pathology</topic><topic>Metastases</topic><topic>Mice</topic><topic>Momordica charantia</topic><topic>Momordica charantia - chemistry</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Obesity</topic><topic>Obesity - diet therapy</topic><topic>Obesity - etiology</topic><topic>Obesity - metabolism</topic><topic>Phenotype</topic><topic>Rodents</topic><topic>Serum levels</topic><topic>Traditional foods</topic><topic>Tumor necrosis factor-α</topic><topic>Type 2 diabetes</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bao, Bin</creatorcontrib><creatorcontrib>Chen, Yan-Guang</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Na Xu, Yan Lin</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Qu, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bao, Bin</au><au>Chen, Yan-Guang</au><au>Zhang, Lei</au><au>Na Xu, Yan Lin</au><au>Wang, Xin</au><au>Liu, Jian</au><au>Qu, Wei</au><au>Fritz, Jörg Hermann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-12-17</date><risdate>2013</risdate><volume>8</volume><issue>12</issue><spage>e84075</spage><epage>e84075</epage><pages>e84075-e84075</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Obesity is a world-wide epidemic disease that correlates closely with type 2 diabetes and cardiovascular diseases. Obesity-induced chronic adipose tissue inflammation is now considered as a critical contributor to the above complications. Momordica charantia (bitter melon, BM) is a traditional Chinese food and well known for its function of reducing body weight gain and insulin resistance. However, it is unclear whether BM could alleviate adipose tissue inflammation caused by obesity. In this study, C57BL/6 mice were fed high fat diet (HFD) with or without BM for 12 weeks. BM-contained diets ameliorated HFD-induced obesity and insulin resistance. Histological and real-time PCR analysis demonstrated BM not only reduced macrophage infiltration into epididymal adipose tissues (EAT) and brown adipose tissues (BAT). Flow cytometry show that BM could modify the M1/M2 phenotype ratio of macrophages in EAT. Further study showed that BM lowered mast cell recruitments in EAT, and depressed pro-inflammatory cytokine monocyte chemotactic protein-1 (MCP-1) expression in EAT and BAT as well as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) expression in EAT. Finally, ELISA analysis showed BM-contained diets also normalized serum levels of the cytokines. In summary, in concert with ameliorated insulin resistance and fat deposition, BM reduced adipose tissue inflammation in diet-induced obese (DIO) mice.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24358329</pmid><doi>10.1371/journal.pone.0084075</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-12, Vol.8 (12), p.e84075-e84075 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1468886312 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adipose tissue Adipose Tissue - metabolism Adipose Tissue - pathology Adiposity Animal tissues Animals Body weight Body weight gain Cardiovascular diseases Complications Cytokines Cytokines - blood Cytokines - metabolism Cytometry Diabetes mellitus Diet Enzyme-linked immunosorbent assay Epidemics Flow cytometry Heart diseases High fat diet House mouse Infiltration Inflammation Inflammation Mediators - blood Inflammation Mediators - metabolism Insulin Insulin Resistance Interleukin 6 Kinases Macrophages Macrophages - metabolism Macrophages - pathology Male Mast Cells - metabolism Mast Cells - pathology Metastases Mice Momordica charantia Momordica charantia - chemistry Monocyte chemoattractant protein 1 Obesity Obesity - diet therapy Obesity - etiology Obesity - metabolism Phenotype Rodents Serum levels Traditional foods Tumor necrosis factor-α Type 2 diabetes Weight reduction |
| title | Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T11%3A13%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Momordica%20charantia%20(Bitter%20Melon)%20reduces%20obesity-associated%20macrophage%20and%20mast%20cell%20infiltration%20as%20well%20as%20inflammatory%20cytokine%20expression%20in%20adipose%20tissues&rft.jtitle=PloS%20one&rft.au=Bao,%20Bin&rft.date=2013-12-17&rft.volume=8&rft.issue=12&rft.spage=e84075&rft.epage=e84075&rft.pages=e84075-e84075&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0084075&rft_dat=%3Cgale_plos_%3EA478243025%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1468886312&rft_id=info:pmid/24358329&rft_galeid=A478243025&rft_doaj_id=oai_doaj_org_article_a802d0d8e03142d98b4c654e040d5307&rfr_iscdi=true |