Myocardial scar identified by magnetic resonance imaging can predict left ventricular functional improvement after coronary artery bypass grafting
Previous studies have shown that viable myocardium predicts recovery of left ventricular (LV) dysfunction after revascularization. Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional re...
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description | Previous studies have shown that viable myocardium predicts recovery of left ventricular (LV) dysfunction after revascularization. Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional recovery in patients undergoing coronary artery bypass grafting (CABG).
From November 2009 to September 2012, 63 patients with reduced left ventricular ejection fraction (LVEF) referred for first-time isolated CABG were prospectively enrolled, 52 were included in final analysis. LV functional parameters and scar tissue were assessed by LGE-CMR at baseline and 6 months after surgery. Patency of grafts was evaluated by computed tomography angiography (CTA) 6 months post-CABG. Predictors for global functional recovery were analyzed.
The baseline LVEF was 32.7 ± 9.2%, which improved to 41.6 ± 11.0% 6 months later and 32/52 patients improved LVEF by ≥ 5%. Multivariate logistic regression analysis showed that the most significant negative predictor for global functional recovery was the number of scar segments (Odds ratio 2.864, 95% Confidence Interval 1.172-6.996, p = 0.021). Receiver-Operator-Characteristic (ROC) analysis demonstrated that ≤ 4 scar segments predicted global functional recovery with a sensitivity and specificity of 85.0% and 87.5%, respectively (AUC = 0.91, p |
doi_str_mv | 10.1371/journal.pone.0081991 |
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From November 2009 to September 2012, 63 patients with reduced left ventricular ejection fraction (LVEF) referred for first-time isolated CABG were prospectively enrolled, 52 were included in final analysis. LV functional parameters and scar tissue were assessed by LGE-CMR at baseline and 6 months after surgery. Patency of grafts was evaluated by computed tomography angiography (CTA) 6 months post-CABG. Predictors for global functional recovery were analyzed.
The baseline LVEF was 32.7 ± 9.2%, which improved to 41.6 ± 11.0% 6 months later and 32/52 patients improved LVEF by ≥ 5%. Multivariate logistic regression analysis showed that the most significant negative predictor for global functional recovery was the number of scar segments (Odds ratio 2.864, 95% Confidence Interval 1.172-6.996, p = 0.021). Receiver-Operator-Characteristic (ROC) analysis demonstrated that ≤ 4 scar segments predicted global functional recovery with a sensitivity and specificity of 85.0% and 87.5%, respectively (AUC = 0.91, p<0.001). Comparison of ROC curves also indicated that scar tissue was superior to viable myocardium in predicting cardiac functional recovery (p<0.001).
Our findings indicated that scar tissue on LGE-CMR is an independent negative predictor of cardiac functional recovery in patients with impaired LV function undergoing CABG. These observations may be helpful for clinicians and cardiovascular surgeons to determine which patients are most likely to benefit from surgical revascularization.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0081991</identifier><identifier>PMID: 24358136</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Angiography ; Cardiac patients ; Cardiomyopathy ; Cardiovascular disease ; CAT scans ; Cicatrix - pathology ; Computed tomography ; Confidence intervals ; Coronary artery ; Coronary Artery Bypass ; Coronary vessels ; Electrocardiography ; Female ; Gadolinium ; Grafting ; Grafts ; Heart ; Heart attacks ; Heart diseases ; Heart failure ; Heart surgery ; Hospitals ; Humans ; Ischemia ; Laboratories ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Medical personnel ; Medical prognosis ; Middle Aged ; Myocardium ; Myocardium - pathology ; NMR ; Nuclear magnetic resonance ; Patients ; Predictive Value of Tests ; Prognosis ; Rare earth metal compounds ; Recovery ; Recovery of function ; Recovery of Function - physiology ; Regression analysis ; Resonance ; Segments ; Sensitivity and Specificity ; Statistical analysis ; Studies ; Surgery ; Tomography ; Treatment Outcome ; Ventricle ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left - physiology</subject><ispartof>PloS one, 2013-12, Vol.8 (12), p.e81991-e81991</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Yang et al 2013 Yang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1a04562bb3605ca6842b8eb085f3c1171327e2c903adb3bb22c2d14a2fb9400c3</citedby><cites>FETCH-LOGICAL-c692t-1a04562bb3605ca6842b8eb085f3c1171327e2c903adb3bb22c2d14a2fb9400c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864907/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864907/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24358136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Guo, Yiru</contributor><creatorcontrib>Yang, Tao</creatorcontrib><creatorcontrib>Lu, Min-Jie</creatorcontrib><creatorcontrib>Sun, Han-Song</creatorcontrib><creatorcontrib>Tang, Yue</creatorcontrib><creatorcontrib>Pan, Shi-Wei</creatorcontrib><creatorcontrib>Zhao, Shi-Hua</creatorcontrib><title>Myocardial scar identified by magnetic resonance imaging can predict left ventricular functional improvement after coronary artery bypass grafting</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Previous studies have shown that viable myocardium predicts recovery of left ventricular (LV) dysfunction after revascularization. Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional recovery in patients undergoing coronary artery bypass grafting (CABG).
From November 2009 to September 2012, 63 patients with reduced left ventricular ejection fraction (LVEF) referred for first-time isolated CABG were prospectively enrolled, 52 were included in final analysis. LV functional parameters and scar tissue were assessed by LGE-CMR at baseline and 6 months after surgery. Patency of grafts was evaluated by computed tomography angiography (CTA) 6 months post-CABG. Predictors for global functional recovery were analyzed.
The baseline LVEF was 32.7 ± 9.2%, which improved to 41.6 ± 11.0% 6 months later and 32/52 patients improved LVEF by ≥ 5%. Multivariate logistic regression analysis showed that the most significant negative predictor for global functional recovery was the number of scar segments (Odds ratio 2.864, 95% Confidence Interval 1.172-6.996, p = 0.021). Receiver-Operator-Characteristic (ROC) analysis demonstrated that ≤ 4 scar segments predicted global functional recovery with a sensitivity and specificity of 85.0% and 87.5%, respectively (AUC = 0.91, p<0.001). Comparison of ROC curves also indicated that scar tissue was superior to viable myocardium in predicting cardiac functional recovery (p<0.001).
Our findings indicated that scar tissue on LGE-CMR is an independent negative predictor of cardiac functional recovery in patients with impaired LV function undergoing CABG. These observations may be helpful for clinicians and cardiovascular surgeons to determine which patients are most likely to benefit from surgical revascularization.</description><subject>Aged</subject><subject>Angiography</subject><subject>Cardiac patients</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>CAT scans</subject><subject>Cicatrix - pathology</subject><subject>Computed tomography</subject><subject>Confidence intervals</subject><subject>Coronary artery</subject><subject>Coronary Artery Bypass</subject><subject>Coronary vessels</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Gadolinium</subject><subject>Grafting</subject><subject>Grafts</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Heart surgery</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical personnel</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Myocardium</subject><subject>Myocardium - pathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Rare earth metal compounds</subject><subject>Recovery</subject><subject>Recovery of function</subject><subject>Recovery of Function - physiology</subject><subject>Regression analysis</subject><subject>Resonance</subject><subject>Segments</subject><subject>Sensitivity and Specificity</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Tomography</subject><subject>Treatment Outcome</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left - physiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWnnG6QqorDSkWVON1ajjPJuvLGWztZsa_BEzNh02qDeoFyEXvmm388Y0-SPGd0yUTO3l37IXTaLbe-gyWlBStL9iA5ZaXgi4xT8fBofZI8ifGa0lQUWfY4OeFSpAUT2Wny-8veGx1qqx2JuCC2hq63jYWaVHuy0W0HvTUkQPSd7gwQizbbtcTojmwD1Nb0xEHTkx0GBmsGhyrN0JneYoRDfhv8DjboJbrpIRDjA3rCnuiA2z3m2eoYSRvQjcpPk0eNdhGeTf-z5MfHD98vPi8urz6tLs4vFyYreb9gmso041UlMpoanRWSVwVUtEgbYRjLmeA5cFNSoetKVBXnhtdMat5UpaTUiLPk5UF363xUUzujYjIrMlqmjCGxOhC119dqG7D0sFdeW_XX4EOrsARrHChqUlFzKQEqIQWkhazwWCIFwWjKc41a76dsQ7WB2ozN0m4mOvd0dq1av1N4ZbKkOQq8mQSCvxkg9mpjowHndAd-GM89UnnJOKKv_kHvr26iWo0F2K7xmNeMoupc5gVPM3w_SC3vofCrYWMNvr3Gon0W8HYWgEwPv_pWDzGq1bev_89e_Zyzr4_YNWjXr6N3w_jM4hyUB9AEH2OA5q7JjKpxdG67ocbRUdPoYNiL4wu6C7qdFfEHHQMWWg</recordid><startdate>20131216</startdate><enddate>20131216</enddate><creator>Yang, Tao</creator><creator>Lu, Min-Jie</creator><creator>Sun, Han-Song</creator><creator>Tang, Yue</creator><creator>Pan, Shi-Wei</creator><creator>Zhao, Shi-Hua</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131216</creationdate><title>Myocardial scar identified by magnetic resonance imaging can predict left ventricular functional improvement after coronary artery bypass grafting</title><author>Yang, Tao ; Lu, Min-Jie ; Sun, Han-Song ; Tang, Yue ; Pan, Shi-Wei ; Zhao, Shi-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1a04562bb3605ca6842b8eb085f3c1171327e2c903adb3bb22c2d14a2fb9400c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Angiography</topic><topic>Cardiac patients</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>CAT scans</topic><topic>Cicatrix - pathology</topic><topic>Computed tomography</topic><topic>Confidence intervals</topic><topic>Coronary artery</topic><topic>Coronary Artery Bypass</topic><topic>Coronary vessels</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Gadolinium</topic><topic>Grafting</topic><topic>Grafts</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart diseases</topic><topic>Heart failure</topic><topic>Heart surgery</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical personnel</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Myocardium</topic><topic>Myocardium - pathology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Rare earth metal compounds</topic><topic>Recovery</topic><topic>Recovery of function</topic><topic>Recovery of Function - physiology</topic><topic>Regression analysis</topic><topic>Resonance</topic><topic>Segments</topic><topic>Sensitivity and Specificity</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Surgery</topic><topic>Tomography</topic><topic>Treatment Outcome</topic><topic>Ventricle</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Tao</creatorcontrib><creatorcontrib>Lu, Min-Jie</creatorcontrib><creatorcontrib>Sun, Han-Song</creatorcontrib><creatorcontrib>Tang, Yue</creatorcontrib><creatorcontrib>Pan, Shi-Wei</creatorcontrib><creatorcontrib>Zhao, Shi-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Tao</au><au>Lu, Min-Jie</au><au>Sun, Han-Song</au><au>Tang, Yue</au><au>Pan, Shi-Wei</au><au>Zhao, Shi-Hua</au><au>Guo, Yiru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial scar identified by magnetic resonance imaging can predict left ventricular functional improvement after coronary artery bypass grafting</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-12-16</date><risdate>2013</risdate><volume>8</volume><issue>12</issue><spage>e81991</spage><epage>e81991</epage><pages>e81991-e81991</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Previous studies have shown that viable myocardium predicts recovery of left ventricular (LV) dysfunction after revascularization. Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional recovery in patients undergoing coronary artery bypass grafting (CABG).
From November 2009 to September 2012, 63 patients with reduced left ventricular ejection fraction (LVEF) referred for first-time isolated CABG were prospectively enrolled, 52 were included in final analysis. LV functional parameters and scar tissue were assessed by LGE-CMR at baseline and 6 months after surgery. Patency of grafts was evaluated by computed tomography angiography (CTA) 6 months post-CABG. Predictors for global functional recovery were analyzed.
The baseline LVEF was 32.7 ± 9.2%, which improved to 41.6 ± 11.0% 6 months later and 32/52 patients improved LVEF by ≥ 5%. Multivariate logistic regression analysis showed that the most significant negative predictor for global functional recovery was the number of scar segments (Odds ratio 2.864, 95% Confidence Interval 1.172-6.996, p = 0.021). Receiver-Operator-Characteristic (ROC) analysis demonstrated that ≤ 4 scar segments predicted global functional recovery with a sensitivity and specificity of 85.0% and 87.5%, respectively (AUC = 0.91, p<0.001). Comparison of ROC curves also indicated that scar tissue was superior to viable myocardium in predicting cardiac functional recovery (p<0.001).
Our findings indicated that scar tissue on LGE-CMR is an independent negative predictor of cardiac functional recovery in patients with impaired LV function undergoing CABG. These observations may be helpful for clinicians and cardiovascular surgeons to determine which patients are most likely to benefit from surgical revascularization.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24358136</pmid><doi>10.1371/journal.pone.0081991</doi><tpages>e81991</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Angiography Cardiac patients Cardiomyopathy Cardiovascular disease CAT scans Cicatrix - pathology Computed tomography Confidence intervals Coronary artery Coronary Artery Bypass Coronary vessels Electrocardiography Female Gadolinium Grafting Grafts Heart Heart attacks Heart diseases Heart failure Heart surgery Hospitals Humans Ischemia Laboratories Magnetic resonance Magnetic Resonance Imaging Male Medical imaging Medical personnel Medical prognosis Middle Aged Myocardium Myocardium - pathology NMR Nuclear magnetic resonance Patients Predictive Value of Tests Prognosis Rare earth metal compounds Recovery Recovery of function Recovery of Function - physiology Regression analysis Resonance Segments Sensitivity and Specificity Statistical analysis Studies Surgery Tomography Treatment Outcome Ventricle Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - physiology |
title | Myocardial scar identified by magnetic resonance imaging can predict left ventricular functional improvement after coronary artery bypass grafting |
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