Myocardial scar identified by magnetic resonance imaging can predict left ventricular functional improvement after coronary artery bypass grafting

Previous studies have shown that viable myocardium predicts recovery of left ventricular (LV) dysfunction after revascularization. Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional re...

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Veröffentlicht in:PloS one 2013-12, Vol.8 (12), p.e81991-e81991
Hauptverfasser: Yang, Tao, Lu, Min-Jie, Sun, Han-Song, Tang, Yue, Pan, Shi-Wei, Zhao, Shi-Hua
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Lu, Min-Jie
Sun, Han-Song
Tang, Yue
Pan, Shi-Wei
Zhao, Shi-Hua
description Previous studies have shown that viable myocardium predicts recovery of left ventricular (LV) dysfunction after revascularization. Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional recovery in patients undergoing coronary artery bypass grafting (CABG). From November 2009 to September 2012, 63 patients with reduced left ventricular ejection fraction (LVEF) referred for first-time isolated CABG were prospectively enrolled, 52 were included in final analysis. LV functional parameters and scar tissue were assessed by LGE-CMR at baseline and 6 months after surgery. Patency of grafts was evaluated by computed tomography angiography (CTA) 6 months post-CABG. Predictors for global functional recovery were analyzed. The baseline LVEF was 32.7 ± 9.2%, which improved to 41.6 ± 11.0% 6 months later and 32/52 patients improved LVEF by ≥ 5%. Multivariate logistic regression analysis showed that the most significant negative predictor for global functional recovery was the number of scar segments (Odds ratio 2.864, 95% Confidence Interval 1.172-6.996, p = 0.021). Receiver-Operator-Characteristic (ROC) analysis demonstrated that ≤ 4 scar segments predicted global functional recovery with a sensitivity and specificity of 85.0% and 87.5%, respectively (AUC = 0.91, p
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Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional recovery in patients undergoing coronary artery bypass grafting (CABG). From November 2009 to September 2012, 63 patients with reduced left ventricular ejection fraction (LVEF) referred for first-time isolated CABG were prospectively enrolled, 52 were included in final analysis. LV functional parameters and scar tissue were assessed by LGE-CMR at baseline and 6 months after surgery. Patency of grafts was evaluated by computed tomography angiography (CTA) 6 months post-CABG. Predictors for global functional recovery were analyzed. The baseline LVEF was 32.7 ± 9.2%, which improved to 41.6 ± 11.0% 6 months later and 32/52 patients improved LVEF by ≥ 5%. Multivariate logistic regression analysis showed that the most significant negative predictor for global functional recovery was the number of scar segments (Odds ratio 2.864, 95% Confidence Interval 1.172-6.996, p = 0.021). Receiver-Operator-Characteristic (ROC) analysis demonstrated that ≤ 4 scar segments predicted global functional recovery with a sensitivity and specificity of 85.0% and 87.5%, respectively (AUC = 0.91, p&lt;0.001). Comparison of ROC curves also indicated that scar tissue was superior to viable myocardium in predicting cardiac functional recovery (p&lt;0.001). Our findings indicated that scar tissue on LGE-CMR is an independent negative predictor of cardiac functional recovery in patients with impaired LV function undergoing CABG. 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pathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Rare earth metal compounds</subject><subject>Recovery</subject><subject>Recovery of function</subject><subject>Recovery of Function - physiology</subject><subject>Regression analysis</subject><subject>Resonance</subject><subject>Segments</subject><subject>Sensitivity and Specificity</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Tomography</subject><subject>Treatment Outcome</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left - physiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWnnG6QqorDSkWVON1ajjPJuvLGWztZsa_BEzNh02qDeoFyEXvmm388Y0-SPGd0yUTO3l37IXTaLbe-gyWlBStL9iA5ZaXgi4xT8fBofZI8ifGa0lQUWfY4OeFSpAUT2Wny-8veGx1qqx2JuCC2hq63jYWaVHuy0W0HvTUkQPSd7gwQizbbtcTojmwD1Nb0xEHTkx0GBmsGhyrN0JneYoRDfhv8DjboJbrpIRDjA3rCnuiA2z3m2eoYSRvQjcpPk0eNdhGeTf-z5MfHD98vPi8urz6tLs4vFyYreb9gmso041UlMpoanRWSVwVUtEgbYRjLmeA5cFNSoetKVBXnhtdMat5UpaTUiLPk5UF363xUUzujYjIrMlqmjCGxOhC119dqG7D0sFdeW_XX4EOrsARrHChqUlFzKQEqIQWkhazwWCIFwWjKc41a76dsQ7WB2ozN0m4mOvd0dq1av1N4ZbKkOQq8mQSCvxkg9mpjowHndAd-GM89UnnJOKKv_kHvr26iWo0F2K7xmNeMoupc5gVPM3w_SC3vofCrYWMNvr3Gon0W8HYWgEwPv_pWDzGq1bev_89e_Zyzr4_YNWjXr6N3w_jM4hyUB9AEH2OA5q7JjKpxdG67ocbRUdPoYNiL4wu6C7qdFfEHHQMWWg</recordid><startdate>20131216</startdate><enddate>20131216</enddate><creator>Yang, Tao</creator><creator>Lu, Min-Jie</creator><creator>Sun, Han-Song</creator><creator>Tang, Yue</creator><creator>Pan, Shi-Wei</creator><creator>Zhao, Shi-Hua</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131216</creationdate><title>Myocardial scar identified by magnetic resonance imaging can predict left ventricular functional improvement after coronary artery bypass grafting</title><author>Yang, Tao ; Lu, Min-Jie ; Sun, Han-Song ; Tang, Yue ; Pan, Shi-Wei ; Zhao, Shi-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1a04562bb3605ca6842b8eb085f3c1171327e2c903adb3bb22c2d14a2fb9400c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Angiography</topic><topic>Cardiac patients</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>CAT scans</topic><topic>Cicatrix - pathology</topic><topic>Computed tomography</topic><topic>Confidence intervals</topic><topic>Coronary artery</topic><topic>Coronary Artery Bypass</topic><topic>Coronary vessels</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Gadolinium</topic><topic>Grafting</topic><topic>Grafts</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart diseases</topic><topic>Heart failure</topic><topic>Heart surgery</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical personnel</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Myocardium</topic><topic>Myocardium - pathology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Rare earth metal compounds</topic><topic>Recovery</topic><topic>Recovery of function</topic><topic>Recovery of Function - 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Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional recovery in patients undergoing coronary artery bypass grafting (CABG). From November 2009 to September 2012, 63 patients with reduced left ventricular ejection fraction (LVEF) referred for first-time isolated CABG were prospectively enrolled, 52 were included in final analysis. LV functional parameters and scar tissue were assessed by LGE-CMR at baseline and 6 months after surgery. Patency of grafts was evaluated by computed tomography angiography (CTA) 6 months post-CABG. Predictors for global functional recovery were analyzed. The baseline LVEF was 32.7 ± 9.2%, which improved to 41.6 ± 11.0% 6 months later and 32/52 patients improved LVEF by ≥ 5%. Multivariate logistic regression analysis showed that the most significant negative predictor for global functional recovery was the number of scar segments (Odds ratio 2.864, 95% Confidence Interval 1.172-6.996, p = 0.021). Receiver-Operator-Characteristic (ROC) analysis demonstrated that ≤ 4 scar segments predicted global functional recovery with a sensitivity and specificity of 85.0% and 87.5%, respectively (AUC = 0.91, p&lt;0.001). Comparison of ROC curves also indicated that scar tissue was superior to viable myocardium in predicting cardiac functional recovery (p&lt;0.001). Our findings indicated that scar tissue on LGE-CMR is an independent negative predictor of cardiac functional recovery in patients with impaired LV function undergoing CABG. These observations may be helpful for clinicians and cardiovascular surgeons to determine which patients are most likely to benefit from surgical revascularization.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24358136</pmid><doi>10.1371/journal.pone.0081991</doi><tpages>e81991</tpages><oa>free_for_read</oa></addata></record>
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subjects Aged
Angiography
Cardiac patients
Cardiomyopathy
Cardiovascular disease
CAT scans
Cicatrix - pathology
Computed tomography
Confidence intervals
Coronary artery
Coronary Artery Bypass
Coronary vessels
Electrocardiography
Female
Gadolinium
Grafting
Grafts
Heart
Heart attacks
Heart diseases
Heart failure
Heart surgery
Hospitals
Humans
Ischemia
Laboratories
Magnetic resonance
Magnetic Resonance Imaging
Male
Medical imaging
Medical personnel
Medical prognosis
Middle Aged
Myocardium
Myocardium - pathology
NMR
Nuclear magnetic resonance
Patients
Predictive Value of Tests
Prognosis
Rare earth metal compounds
Recovery
Recovery of function
Recovery of Function - physiology
Regression analysis
Resonance
Segments
Sensitivity and Specificity
Statistical analysis
Studies
Surgery
Tomography
Treatment Outcome
Ventricle
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left - physiology
title Myocardial scar identified by magnetic resonance imaging can predict left ventricular functional improvement after coronary artery bypass grafting
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