Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects

The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation. Using SNP data from genome-wide studies, we imputed and teste...

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Veröffentlicht in:	PLoS genetics 2013-11, Vol.9 (11), p.e1003926
Hauptverfasser:	Patsopoulos, Nikolaos A, Barcellos, Lisa F, Hintzen, Rogier Q, Schaefer, Catherine, van Duijn, Cornelia M, Noble, Janelle A, Raj, Towfique, Gourraud, Pierre-Antoine, Stranger, Barbara E, Oksenberg, Jorge, Olsson, Tomas, Taylor, Bruce V, Sawcer, Stephen, Hafler, David A, Carrington, Mary, De Jager, Philip L, de Bakker, Paul I W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino acids Biomedical research Chromosome Mapping Councils Genetic aspects Genetic Predisposition to Disease Genetic screening Genome-Wide Association Study Genomes Haplotypes Health aspects Histocompatibility antigens Histocompatibility Antigens Class I - genetics HLA histocompatibility antigens HLA-DP beta-Chains - genetics HLA-DRB1 Chains - genetics Humans Intracellular Signaling Peptides and Proteins Linkage Disequilibrium Major histocompatibility complex Major Histocompatibility Complex - genetics Medical research Membrane Proteins - genetics Methods Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - pathology Physiological aspects Polymorphism, Single Nucleotide Receptors, Tumor Necrosis Factor, Type I - genetics Studies
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