Inhibition of the Smc5/6 complex during meiosis perturbs joint molecule formation and resolution without significantly changing crossover or non-crossover levels

Meiosis is a specialized cell division used by diploid organisms to form haploid gametes for sexual reproduction. Central to this reductive division is repair of endogenous DNA double-strand breaks (DSBs) induced by the meiosis-specific enzyme Spo11. These DSBs are repaired in a process called homol...

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Veröffentlicht in:	PLoS genetics 2013-11, Vol.9 (11), p.e1003898-e1003898
Hauptverfasser:	Lilienthal, Ingrid, Kanno, Takaharu, Sjögren, Camilla
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell division Chromatids - genetics Chromosome Segregation - genetics Chromosomes Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA repair DNA Repair - genetics Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Enzymes Experiments Gene expression Genetic diversity Meiosis Meiosis - genetics Mice Mitosis - genetics Molecular genetics Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Organisms Proteins Recombination, Genetic Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sister Chromatid Exchange Yeast
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