Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells

Translation is divided into initiation, elongation, termination and ribosome recycling. Earlier work implicated several eukaryotic initiation factors (eIFs) in ribosomal recycling in vitro. Here, we uncover roles for HCR1 and eIF3 in translation termination in vivo. A substantial proportion of eIF3,...

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Veröffentlicht in:	PLoS genetics 2013-11, Vol.9 (11), p.e1003962-e1003962
Hauptverfasser:	Beznosková, Petra, Cuchalová, Lucie, Wagner, Susan, Shoemaker, Christopher J, Gunišová, Stanislava, von der Haar, Tobias, Valášek, Leoš Shivaya
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence ATP-Binding Cassette Transporters - genetics Codon, Terminator - genetics Eukaryotic Initiation Factor-3 - genetics Experiments Mutation Peptide Chain Termination, Translational Peptide Initiation Factors - genetics Plasmids Protein Binding Protein Biosynthesis Protein synthesis Proteins Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Yeast
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