Natural selection promotes antigenic evolvability

The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide...

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Veröffentlicht in:	PLoS pathogens 2013-11, Vol.9 (11), p.e1003766-e1003766
Hauptverfasser:	Graves, Christopher J, Ros, Vera I D, Stevenson, Brian, Sniegowski, Paul D, Brisson, Dustin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological adaptive evolution Animals Antigens, Bacterial - genetics Antigens, Bacterial - immunology Borrelia burgdorferi - genetics Borrelia burgdorferi - immunology Borrelia burgdorferi - metabolism borrelia-burgdorferi concerted evolution Deoxyribonucleic acid DNA Evolution Evolution, Molecular gene conversion Genetic aspects Genetic diversity Genetic variation Host-parasite relationships Humans Hypotheses Lyme disease Lyme Disease - genetics Lyme Disease - immunology Lyme Disease - metabolism lyme-disease spirochete Mutation Natural selection parasite virulence Population Proteins Selection, Genetic sequence strand-break repair surface-proteins tandem repeats
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