Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010
Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders...
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| creator | Ferrari, Alize J Charlson, Fiona J Norman, Rosana E Patten, Scott B Freedman, Greg Murray, Christopher J L Vos, Theo Whiteford, Harvey A |
| description | Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease.
Burden was calculated for major depressive disorder (MDD) and dysthymia. A systematic review of epidemiological data was conducted. The data were pooled using a Bayesian meta-regression. Disability weights from population survey data quantified the severity of health loss from depressive disorders. These weights were used to calculate years lived with disability (YLDs) and disability adjusted life years (DALYs). Separate DALYs were estimated for suicide and ischemic heart disease attributable to depressive disorders. Depressive disorders were the second leading cause of YLDs in 2010. MDD accounted for 8.2% (5.9%-10.8%) of global YLDs and dysthymia for 1.4% (0.9%-2.0%). Depressive disorders were a leading cause of DALYs even though no mortality was attributed to them as the underlying cause. MDD accounted for 2.5% (1.9%-3.2%) of global DALYs and dysthymia for 0.5% (0.3%-0.6%). There was more regional variation in burden for MDD than for dysthymia; with higher estimates in females, and adults of working age. Whilst burden increased by 37.5% between 1990 and 2010, this was due to population growth and ageing. MDD explained 16 million suicide DALYs and almost 4 million ischemic heart disease DALYs. This attributable burden would increase the overall burden of depressive disorders from 3.0% (2.2%-3.8%) to 3.8% (3.0%-4.7%) of global DALYs.
GBD 2010 identified depressive disorders as a leading cause of burden. MDD was also a contributor of burden allocated to suicide and ischemic heart disease. These findings emphasize the importance of including depressive disorders as a public-health priority and implementing cost-effective interventions to reduce its burden. Please see later in the article for the Editors' Summary. |
| doi_str_mv | 10.1371/journal.pmed.1001547 |
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Burden was calculated for major depressive disorder (MDD) and dysthymia. A systematic review of epidemiological data was conducted. The data were pooled using a Bayesian meta-regression. Disability weights from population survey data quantified the severity of health loss from depressive disorders. These weights were used to calculate years lived with disability (YLDs) and disability adjusted life years (DALYs). Separate DALYs were estimated for suicide and ischemic heart disease attributable to depressive disorders. Depressive disorders were the second leading cause of YLDs in 2010. MDD accounted for 8.2% (5.9%-10.8%) of global YLDs and dysthymia for 1.4% (0.9%-2.0%). Depressive disorders were a leading cause of DALYs even though no mortality was attributed to them as the underlying cause. MDD accounted for 2.5% (1.9%-3.2%) of global DALYs and dysthymia for 0.5% (0.3%-0.6%). There was more regional variation in burden for MDD than for dysthymia; with higher estimates in females, and adults of working age. Whilst burden increased by 37.5% between 1990 and 2010, this was due to population growth and ageing. MDD explained 16 million suicide DALYs and almost 4 million ischemic heart disease DALYs. This attributable burden would increase the overall burden of depressive disorders from 3.0% (2.2%-3.8%) to 3.8% (3.0%-4.7%) of global DALYs.
GBD 2010 identified depressive disorders as a leading cause of burden. MDD was also a contributor of burden allocated to suicide and ischemic heart disease. These findings emphasize the importance of including depressive disorders as a public-health priority and implementing cost-effective interventions to reduce its burden. Please see later in the article for the Editors' Summary.</description><identifier>ISSN: 1549-1676</identifier><identifier>ISSN: 1549-1277</identifier><identifier>EISSN: 1549-1676</identifier><identifier>DOI: 10.1371/journal.pmed.1001547</identifier><identifier>PMID: 24223526</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Cost of Illness ; Depression ; Depression, Mental ; Depressive Disorder - complications ; Disabled Persons ; Drug therapy ; Female ; Global Health ; Health Surveys ; Humans ; Infant ; Male ; Medical research ; Mental depression ; Middle Aged ; Myocardial Ischemia ; Prevalence studies (Epidemiology) ; Public Health ; Quality-Adjusted Life Years ; Risk Factors ; Sex Factors ; Social aspects ; Social medicine ; Studies ; Suicide ; Teenagers ; Young Adult</subject><ispartof>PLoS medicine, 2013-11, Vol.10 (11), p.e1001547-e1001547</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Ferrari et al 2013 Ferrari et al</rights><rights>2013 Ferrari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, et al. (2013) Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010. PLoS Med 10(11): e1001547. doi:10.1371/journal.pmed.1001547</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c787t-c176fdeb691867b1490b8614eaf32e82845ad7f94b40550b858497f5990a56903</citedby><cites>FETCH-LOGICAL-c787t-c176fdeb691867b1490b8614eaf32e82845ad7f94b40550b858497f5990a56903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818162/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818162/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24223526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hay, Phillipa J.</contributor><creatorcontrib>Ferrari, Alize J</creatorcontrib><creatorcontrib>Charlson, Fiona J</creatorcontrib><creatorcontrib>Norman, Rosana E</creatorcontrib><creatorcontrib>Patten, Scott B</creatorcontrib><creatorcontrib>Freedman, Greg</creatorcontrib><creatorcontrib>Murray, Christopher J L</creatorcontrib><creatorcontrib>Vos, Theo</creatorcontrib><creatorcontrib>Whiteford, Harvey A</creatorcontrib><title>Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010</title><title>PLoS medicine</title><addtitle>PLoS Med</addtitle><description>Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease.
Burden was calculated for major depressive disorder (MDD) and dysthymia. A systematic review of epidemiological data was conducted. The data were pooled using a Bayesian meta-regression. Disability weights from population survey data quantified the severity of health loss from depressive disorders. These weights were used to calculate years lived with disability (YLDs) and disability adjusted life years (DALYs). Separate DALYs were estimated for suicide and ischemic heart disease attributable to depressive disorders. Depressive disorders were the second leading cause of YLDs in 2010. MDD accounted for 8.2% (5.9%-10.8%) of global YLDs and dysthymia for 1.4% (0.9%-2.0%). Depressive disorders were a leading cause of DALYs even though no mortality was attributed to them as the underlying cause. MDD accounted for 2.5% (1.9%-3.2%) of global DALYs and dysthymia for 0.5% (0.3%-0.6%). There was more regional variation in burden for MDD than for dysthymia; with higher estimates in females, and adults of working age. Whilst burden increased by 37.5% between 1990 and 2010, this was due to population growth and ageing. MDD explained 16 million suicide DALYs and almost 4 million ischemic heart disease DALYs. This attributable burden would increase the overall burden of depressive disorders from 3.0% (2.2%-3.8%) to 3.8% (3.0%-4.7%) of global DALYs.
GBD 2010 identified depressive disorders as a leading cause of burden. MDD was also a contributor of burden allocated to suicide and ischemic heart disease. These findings emphasize the importance of including depressive disorders as a public-health priority and implementing cost-effective interventions to reduce its burden. Please see later in the article for the Editors' Summary.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cost of Illness</subject><subject>Depression</subject><subject>Depression, Mental</subject><subject>Depressive Disorder - complications</subject><subject>Disabled Persons</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Global Health</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical research</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Public Health</subject><subject>Quality-Adjusted Life Years</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Social aspects</subject><subject>Social medicine</subject><subject>Studies</subject><subject>Suicide</subject><subject>Teenagers</subject><subject>Young Adult</subject><issn>1549-1676</issn><issn>1549-1277</issn><issn>1549-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqVk21rFDEQxxdRbK1-A9GAIAq9M9k8bXwh1OLDQbHg09uQ3czupewlZ7Jbet_enHetd3AvlEAmzPzmPyGTKYqnBE8JleTNVRijN_10uQA7JRgTzuS94jgbNSFCivs756PiUUpXGJcKK_ywOCpZWVJeiuNieD9GCx6FFllYRkjJXQOyLoXsjgnVK9SE0Q9xdYoS3Jwi00HevEUrMPEtap23zncJtTEs0DAH1PWhNj2q_-q6BCYBSsNoV6jEBD8uHrSmT_Bka0-KHx8_fD__PLm4_DQ7P7uYNLKSw6QhUrQWaqFIJWRNmMJ1JQgD09ISqrJi3FjZKlYzzHmO8Yop2XKlsOFCYXpSPN_oLvuQ9PbBkiZMVFwSgmkmZhvCBnOll9EtTFzpYJz-4wix0yYOrulB58q5XImlAMWYLQ2XlnFLSjDWUFxlrXfbamOde9JAfjXT74nuR7yb6y5ca1qRiogyC7zaCsTwa4Q06IVLDfS98RDG9b15xXFuG8noiw3amXw159uQFZs1rs8op0JRKteCkwNUBx5y-eChddm9x08P8HlZWLjmYMLrvYTMDHAzdGZMSc--ff0P9su_s5c_99mXO-wcTD_MU-jHwQWf9kG2AZsYUorQ3rWGYL0eqdsfotcjpbcjldOe7bb1Lul2huhvQLoY0Q</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Ferrari, Alize J</creator><creator>Charlson, Fiona J</creator><creator>Norman, Rosana E</creator><creator>Patten, Scott B</creator><creator>Freedman, Greg</creator><creator>Murray, Christopher J L</creator><creator>Vos, Theo</creator><creator>Whiteford, Harvey A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>CZK</scope></search><sort><creationdate>20131101</creationdate><title>Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010</title><author>Ferrari, Alize J ; 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Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease.
Burden was calculated for major depressive disorder (MDD) and dysthymia. A systematic review of epidemiological data was conducted. The data were pooled using a Bayesian meta-regression. Disability weights from population survey data quantified the severity of health loss from depressive disorders. These weights were used to calculate years lived with disability (YLDs) and disability adjusted life years (DALYs). Separate DALYs were estimated for suicide and ischemic heart disease attributable to depressive disorders. Depressive disorders were the second leading cause of YLDs in 2010. MDD accounted for 8.2% (5.9%-10.8%) of global YLDs and dysthymia for 1.4% (0.9%-2.0%). Depressive disorders were a leading cause of DALYs even though no mortality was attributed to them as the underlying cause. MDD accounted for 2.5% (1.9%-3.2%) of global DALYs and dysthymia for 0.5% (0.3%-0.6%). There was more regional variation in burden for MDD than for dysthymia; with higher estimates in females, and adults of working age. Whilst burden increased by 37.5% between 1990 and 2010, this was due to population growth and ageing. MDD explained 16 million suicide DALYs and almost 4 million ischemic heart disease DALYs. This attributable burden would increase the overall burden of depressive disorders from 3.0% (2.2%-3.8%) to 3.8% (3.0%-4.7%) of global DALYs.
GBD 2010 identified depressive disorders as a leading cause of burden. MDD was also a contributor of burden allocated to suicide and ischemic heart disease. These findings emphasize the importance of including depressive disorders as a public-health priority and implementing cost-effective interventions to reduce its burden. Please see later in the article for the Editors' Summary.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24223526</pmid><doi>10.1371/journal.pmed.1001547</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Child Child, Preschool Cost of Illness Depression Depression, Mental Depressive Disorder - complications Disabled Persons Drug therapy Female Global Health Health Surveys Humans Infant Male Medical research Mental depression Middle Aged Myocardial Ischemia Prevalence studies (Epidemiology) Public Health Quality-Adjusted Life Years Risk Factors Sex Factors Social aspects Social medicine Studies Suicide Teenagers Young Adult |
| title | Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010 |
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