Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study
Advanced glycation end product (AGE) accumulation is thought to be a measure of cumulative metabolic stress that has been reported to independently predict cardiovascular disease in diabetes and renal failure. The aim of this study was to evaluate the association between AGE accumulation, measured a...
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| creator | Tanaka, Kenichi Nakayama, Masaaki Kanno, Makoto Kimura, Hiroshi Watanabe, Kimio Tani, Yoshihiro Kusano, Yuki Suzuki, Hodaka Hayashi, Yoshimitsu Asahi, Koichi Sato, Keiji Miyata, Toshio Watanabe, Tsuyoshi |
| description | Advanced glycation end product (AGE) accumulation is thought to be a measure of cumulative metabolic stress that has been reported to independently predict cardiovascular disease in diabetes and renal failure. The aim of this study was to evaluate the association between AGE accumulation, measured as skin autofluorescence, and the progression of renal disease in pre-dialysis patients with chronic kidney disease (CKD).
Skin autofluorescence was measured noninvasively with an autofluorescence reader at baseline in 449 pre-dialysis patients with CKD. The primary end point was defined as a doubling of serum creatinine and/or need for dialysis.
Thirty-three patients were lost to follow-up. Forty six patients reached the primary end point during the follow-up period (Median 39 months). Kaplan-Meier analysis showed a significantly higher risk of development of the primary end points in patients with skin autofluorescence levels above the optimal cut-off level of 2.31 arbitrary units, derived by receiver operator curve analysis. Cox regression analysis revealed that skin autofluorescence was an independent predictor of the primary end point, even after adjustment for age, gender, smoking history, diabetes, estimated glomerular filtration rate and proteinuria (adjusted hazard ratio 2.58, P = 0.004).
Tissue accumulation of AGEs, measured as skin autofluorescence, is a strong and independent predictor of progression of CKD. Skin autofluorescence may be useful for risk stratification in this group of patients; further studies should clarify whether AGE accumulation could be one of the therapeutic targets to improve the prognosis of CKD. |
| doi_str_mv | 10.1371/journal.pone.0083799 |
| format | Article |
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Skin autofluorescence was measured noninvasively with an autofluorescence reader at baseline in 449 pre-dialysis patients with CKD. The primary end point was defined as a doubling of serum creatinine and/or need for dialysis.
Thirty-three patients were lost to follow-up. Forty six patients reached the primary end point during the follow-up period (Median 39 months). Kaplan-Meier analysis showed a significantly higher risk of development of the primary end points in patients with skin autofluorescence levels above the optimal cut-off level of 2.31 arbitrary units, derived by receiver operator curve analysis. Cox regression analysis revealed that skin autofluorescence was an independent predictor of the primary end point, even after adjustment for age, gender, smoking history, diabetes, estimated glomerular filtration rate and proteinuria (adjusted hazard ratio 2.58, P = 0.004).
Tissue accumulation of AGEs, measured as skin autofluorescence, is a strong and independent predictor of progression of CKD. Skin autofluorescence may be useful for risk stratification in this group of patients; further studies should clarify whether AGE accumulation could be one of the therapeutic targets to improve the prognosis of CKD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0083799</identifier><identifier>PMID: 24349550</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accumulation ; Adult ; Age ; Aged ; Arthritis ; Atherosclerosis ; Bioaccumulation ; Cardiovascular disease ; Cardiovascular diseases ; Cholesterol ; Chronic kidney failure ; Creatinine ; Departments ; Development and progression ; Diabetes ; Diabetes mellitus ; Dialysis ; Disease Progression ; Female ; Fluorescence ; Glomerular filtration rate ; Glycation End Products, Advanced - metabolism ; Glycosylation ; Hemodialysis ; Hospitals ; Humans ; Hypertension ; Kidney diseases ; Kidney transplantation ; Laboratories ; Male ; Measurement methods ; Medical research ; Metabolism ; Middle Aged ; Nephrology ; Observational studies ; Patients ; Prospective Studies ; Proteins ; Proteinuria ; Regression analysis ; Renal failure ; Renal Insufficiency, Chronic - metabolism ; Renal Insufficiency, Chronic - pathology ; Skin ; Skin - metabolism ; Skin - pathology ; Skin diseases ; Smoking ; Time Factors ; Transplants & implants</subject><ispartof>PloS one, 2013-12, Vol.8 (12), p.e83799-e83799</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Tanaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Tanaka et al 2013 Tanaka et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-862d8f93d47ed1dc3bfe6af9a1d76e925a3bb3128c45702f400a6e9cb55578613</citedby><cites>FETCH-LOGICAL-c692t-862d8f93d47ed1dc3bfe6af9a1d76e925a3bb3128c45702f400a6e9cb55578613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861518/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861518/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24349550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>James, Leighton R.</contributor><creatorcontrib>Tanaka, Kenichi</creatorcontrib><creatorcontrib>Nakayama, Masaaki</creatorcontrib><creatorcontrib>Kanno, Makoto</creatorcontrib><creatorcontrib>Kimura, Hiroshi</creatorcontrib><creatorcontrib>Watanabe, Kimio</creatorcontrib><creatorcontrib>Tani, Yoshihiro</creatorcontrib><creatorcontrib>Kusano, Yuki</creatorcontrib><creatorcontrib>Suzuki, Hodaka</creatorcontrib><creatorcontrib>Hayashi, Yoshimitsu</creatorcontrib><creatorcontrib>Asahi, Koichi</creatorcontrib><creatorcontrib>Sato, Keiji</creatorcontrib><creatorcontrib>Miyata, Toshio</creatorcontrib><creatorcontrib>Watanabe, Tsuyoshi</creatorcontrib><title>Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Advanced glycation end product (AGE) accumulation is thought to be a measure of cumulative metabolic stress that has been reported to independently predict cardiovascular disease in diabetes and renal failure. The aim of this study was to evaluate the association between AGE accumulation, measured as skin autofluorescence, and the progression of renal disease in pre-dialysis patients with chronic kidney disease (CKD).
Skin autofluorescence was measured noninvasively with an autofluorescence reader at baseline in 449 pre-dialysis patients with CKD. The primary end point was defined as a doubling of serum creatinine and/or need for dialysis.
Thirty-three patients were lost to follow-up. Forty six patients reached the primary end point during the follow-up period (Median 39 months). Kaplan-Meier analysis showed a significantly higher risk of development of the primary end points in patients with skin autofluorescence levels above the optimal cut-off level of 2.31 arbitrary units, derived by receiver operator curve analysis. Cox regression analysis revealed that skin autofluorescence was an independent predictor of the primary end point, even after adjustment for age, gender, smoking history, diabetes, estimated glomerular filtration rate and proteinuria (adjusted hazard ratio 2.58, P = 0.004).
Tissue accumulation of AGEs, measured as skin autofluorescence, is a strong and independent predictor of progression of CKD. Skin autofluorescence may be useful for risk stratification in this group of patients; further studies should clarify whether AGE accumulation could be one of the therapeutic targets to improve the prognosis of CKD.</description><subject>Accumulation</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Arthritis</subject><subject>Atherosclerosis</subject><subject>Bioaccumulation</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol</subject><subject>Chronic kidney failure</subject><subject>Creatinine</subject><subject>Departments</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Dialysis</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Glomerular filtration rate</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>Glycosylation</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Laboratories</subject><subject>Male</subject><subject>Measurement methods</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Proteinuria</subject><subject>Regression analysis</subject><subject>Renal failure</subject><subject>Renal Insufficiency, Chronic - metabolism</subject><subject>Renal Insufficiency, Chronic - pathology</subject><subject>Skin</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin diseases</subject><subject>Smoking</subject><subject>Time Factors</subject><subject>Transplants & implants</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBYQkJw2MWOHSfhgFRVfKxUqRIFrtasM9m4zcZb21nYf4_TTasN6gH5EGvyvGP7nZkkecnonPGcfbiyveugnW9sh3NKC56X5aPkmJU8ncmU8scH-6PkmfdXlGa8kPJpcpQKLsoso8dJf3ltOgJ9sHXbW4deY6eRGE_Ae6sNBKzIbxMaEhokG2dXkfHGdsTWRDfOdkaTa1N1uCOV8QgePxIYQL9BHcwWiV16dFsIUQQt8aGvds-TJzW0Hl-M35Pk55fPP86-zc4vvi7OTs9nWpZpmBUyrYq65JXIsWKV5ssaJdQlsCqXWKYZ8OWSs7TQIstpWgtKIcb1MsuyvJCMnySv93k3rfVqdMwrJmQu84JnRSQWe6KycKU2zqzB7ZQFo24D1q0UuGB0iyqKoNRclnkKgkUrU2Cp0BwzoaPHZcz1aTytX66xik4GB-0k6fRPZxq1slsVq8IyNlzm3ZjA2ZsefVBrEwvSttCh7W_vXUohKaURffMP-vDrRmoF8QGmq208Vw9J1amICIttIyI1f4CKq8K10bG9ahPjE8H7iSAyAf-EFfTeq8Xl9_9nL35N2bcHbIPQhsbbth9ax09BsQd17DPvsL43mVE1TMedG2qYDjVOR5S9OizQvehuHPhfFuYLPA</recordid><startdate>20131212</startdate><enddate>20131212</enddate><creator>Tanaka, Kenichi</creator><creator>Nakayama, Masaaki</creator><creator>Kanno, Makoto</creator><creator>Kimura, Hiroshi</creator><creator>Watanabe, Kimio</creator><creator>Tani, Yoshihiro</creator><creator>Kusano, Yuki</creator><creator>Suzuki, Hodaka</creator><creator>Hayashi, Yoshimitsu</creator><creator>Asahi, Koichi</creator><creator>Sato, Keiji</creator><creator>Miyata, Toshio</creator><creator>Watanabe, Tsuyoshi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131212</creationdate><title>Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study</title><author>Tanaka, Kenichi ; Nakayama, Masaaki ; Kanno, Makoto ; Kimura, Hiroshi ; Watanabe, Kimio ; Tani, Yoshihiro ; Kusano, Yuki ; Suzuki, Hodaka ; Hayashi, Yoshimitsu ; Asahi, Koichi ; Sato, Keiji ; Miyata, Toshio ; Watanabe, Tsuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-862d8f93d47ed1dc3bfe6af9a1d76e925a3bb3128c45702f400a6e9cb55578613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Accumulation</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Arthritis</topic><topic>Atherosclerosis</topic><topic>Bioaccumulation</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol</topic><topic>Chronic kidney failure</topic><topic>Creatinine</topic><topic>Departments</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Dialysis</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Glomerular filtration rate</topic><topic>Glycation End Products, Advanced - metabolism</topic><topic>Glycosylation</topic><topic>Hemodialysis</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Kidney diseases</topic><topic>Kidney transplantation</topic><topic>Laboratories</topic><topic>Male</topic><topic>Measurement methods</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Observational studies</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Proteinuria</topic><topic>Regression analysis</topic><topic>Renal failure</topic><topic>Renal Insufficiency, Chronic - metabolism</topic><topic>Renal Insufficiency, Chronic - pathology</topic><topic>Skin</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>Skin diseases</topic><topic>Smoking</topic><topic>Time Factors</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Kenichi</creatorcontrib><creatorcontrib>Nakayama, Masaaki</creatorcontrib><creatorcontrib>Kanno, Makoto</creatorcontrib><creatorcontrib>Kimura, Hiroshi</creatorcontrib><creatorcontrib>Watanabe, Kimio</creatorcontrib><creatorcontrib>Tani, Yoshihiro</creatorcontrib><creatorcontrib>Kusano, Yuki</creatorcontrib><creatorcontrib>Suzuki, Hodaka</creatorcontrib><creatorcontrib>Hayashi, Yoshimitsu</creatorcontrib><creatorcontrib>Asahi, Koichi</creatorcontrib><creatorcontrib>Sato, Keiji</creatorcontrib><creatorcontrib>Miyata, Toshio</creatorcontrib><creatorcontrib>Watanabe, Tsuyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Kenichi</au><au>Nakayama, Masaaki</au><au>Kanno, Makoto</au><au>Kimura, Hiroshi</au><au>Watanabe, Kimio</au><au>Tani, Yoshihiro</au><au>Kusano, Yuki</au><au>Suzuki, Hodaka</au><au>Hayashi, Yoshimitsu</au><au>Asahi, Koichi</au><au>Sato, Keiji</au><au>Miyata, Toshio</au><au>Watanabe, Tsuyoshi</au><au>James, Leighton R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-12-12</date><risdate>2013</risdate><volume>8</volume><issue>12</issue><spage>e83799</spage><epage>e83799</epage><pages>e83799-e83799</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Advanced glycation end product (AGE) accumulation is thought to be a measure of cumulative metabolic stress that has been reported to independently predict cardiovascular disease in diabetes and renal failure. The aim of this study was to evaluate the association between AGE accumulation, measured as skin autofluorescence, and the progression of renal disease in pre-dialysis patients with chronic kidney disease (CKD).
Skin autofluorescence was measured noninvasively with an autofluorescence reader at baseline in 449 pre-dialysis patients with CKD. The primary end point was defined as a doubling of serum creatinine and/or need for dialysis.
Thirty-three patients were lost to follow-up. Forty six patients reached the primary end point during the follow-up period (Median 39 months). Kaplan-Meier analysis showed a significantly higher risk of development of the primary end points in patients with skin autofluorescence levels above the optimal cut-off level of 2.31 arbitrary units, derived by receiver operator curve analysis. Cox regression analysis revealed that skin autofluorescence was an independent predictor of the primary end point, even after adjustment for age, gender, smoking history, diabetes, estimated glomerular filtration rate and proteinuria (adjusted hazard ratio 2.58, P = 0.004).
Tissue accumulation of AGEs, measured as skin autofluorescence, is a strong and independent predictor of progression of CKD. Skin autofluorescence may be useful for risk stratification in this group of patients; further studies should clarify whether AGE accumulation could be one of the therapeutic targets to improve the prognosis of CKD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24349550</pmid><doi>10.1371/journal.pone.0083799</doi><tpages>e83799</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1467678358 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Accumulation Adult Age Aged Arthritis Atherosclerosis Bioaccumulation Cardiovascular disease Cardiovascular diseases Cholesterol Chronic kidney failure Creatinine Departments Development and progression Diabetes Diabetes mellitus Dialysis Disease Progression Female Fluorescence Glomerular filtration rate Glycation End Products, Advanced - metabolism Glycosylation Hemodialysis Hospitals Humans Hypertension Kidney diseases Kidney transplantation Laboratories Male Measurement methods Medical research Metabolism Middle Aged Nephrology Observational studies Patients Prospective Studies Proteins Proteinuria Regression analysis Renal failure Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Skin Skin - metabolism Skin - pathology Skin diseases Smoking Time Factors Transplants & implants |
| title | Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T18%3A37%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Skin%20autofluorescence%20is%20associated%20with%20the%20progression%20of%20chronic%20kidney%20disease:%20a%20prospective%20observational%20study&rft.jtitle=PloS%20one&rft.au=Tanaka,%20Kenichi&rft.date=2013-12-12&rft.volume=8&rft.issue=12&rft.spage=e83799&rft.epage=e83799&rft.pages=e83799-e83799&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0083799&rft_dat=%3Cgale_plos_%3EA478310834%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1467678358&rft_id=info:pmid/24349550&rft_galeid=A478310834&rft_doaj_id=oai_doaj_org_article_467a9c36972a415382a124c3e54c2039&rfr_iscdi=true |