Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport

Hypoxic tumor microenvironments result in an aggressive phenotype and resistance to therapy that lead to tumor progression, recurrence, and metastasis. While poor vascularization and the resultant inadequate drug delivery are known to contribute to drug resistance, the effect of hypoxia on molecular...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e81869-e81869
Hauptverfasser:	Kakkad, Samata M, Penet, Marie-France, Akhbardeh, Alireza, Pathak, Arvind P, Solaiyappan, Meiyappan, Raman, Venu, Leibfritz, Dieter, Glunde, Kristine, Bhujwalla, Zaver M
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biological Transport Breast cancer Breast Neoplasms - blood supply Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer metastasis Cancer therapies Cell Engineering Cell Line, Tumor Chemotherapy Clustering Collagen Collagen (type I) Collagen Type I - biosynthesis Collagen Type I - ultrastructure Development and progression Drainage measurement Drug delivery Drug delivery systems Drug resistance Exhibitions Extracellular matrix Extracellular Matrix - drug effects Female Fibers Finite element method Fluorescence Gene expression Genes, Reporter Humans Hypoxia Hypoxia - drug therapy Hypoxia - metabolism Hypoxia - pathology Luminescent Proteins - genetics Luminescent Proteins - metabolism Macromolecules Magnetic resonance Magnetic Resonance Imaging Medical research Medicine Metastases Metastasis Mice Mice, SCID Microenvironments Microscopy Microscopy, Fluorescence Morphology Neoplasm Transplantation Neovascularization, Pathologic NMR Nuclear magnetic resonance Pancreatic cancer Prostate Radiology Red Fluorescent Protein Registration Science Second harmonic generation Transplantation, Heterologous Transport Tumor Microenvironment Tumors Vascularization Xenografts
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