TLR2 ligands induce NF-κB activation from endosomal compartments of human monocytes

Localization of Toll-like receptors (TLR) in subcellular organelles is a major strategy to regulate innate immune responses. While TLR4, a cell-surface receptor, signals from both the plasma membrane and endosomal compartments, less is known about the functional role of endosomal trafficking upon TL...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e80743-e80743
Hauptverfasser:	Brandt, Karim J, Fickentscher, Céline, Kruithof, Egbert K O, de Moerloose, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Binding sites Blotting, Western CD14 antigen Cell activation Cell Line Cell surface Cells, Cultured Clathrin Clathrin - metabolism Compartments Dynamin Endocytosis Endocytosis - drug effects Endosomes - drug effects Endosomes - metabolism Enzymes Flow Cytometry Humans Immune response Immune system Immunoassay Immunoglobulins Innate immunity Internalization Ligands Lipopeptides - pharmacology Lipopolysaccharides - pharmacology Localization Medicine Monocytes Monocytes - drug effects Monocytes - metabolism NF-kappa B - metabolism NF-κB protein Organelles Proteins Real-Time Polymerase Chain Reaction Receptors Signal transduction Signaling Staphylococcus aureus Teichoic Acids - pharmacology TLR2 protein TLR4 protein Toll-Like Receptor 2 - agonists Toll-Like Receptor 2 - metabolism Toll-like receptors Tumor necrosis factor-TNF
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