ESAT-6 (EsxA) and TB10.4 (EsxH) based vaccines for pre- and post-exposure tuberculosis vaccination

The ESX systems from Mycobacterium tuberculosis are responsible for the secretion of highly immunogenic proteins of key importance for bacterial survival and growth. The two prototypic proteins, ESAT-6 (EsxA from ESX-1) and TB10.4 (EsxH from ESX-3) share a lot of characteristics regarding genome org...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e80579-e80579
Hauptverfasser:	Hoang, Truc, Aagaard, Claus, Dietrich, Jes, Cassidy, Joseph P, Dolganov, Gregory, Schoolnik, Gary K, Lundberg, Carina Vingsbo, Agger, Else Marie, Andersen, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Antigens Antigens, Bacterial - immunology Apoptosis Bacteria Bacterial physiology Bacterial Proteins - immunology Binding sites Bioinformatics CD4 antigen CD4-Positive T-Lymphocytes - immunology Clinical trials ESAT-6 antigen Exposure Female Fusion protein Gene expression Genomes Immune system Immunogenicity Immunology Infections Infectious diseases Lymphocytes Lymphocytes T Mice Mice, Inbred BALB C Mice, Inbred C57BL Mycobacterium tuberculosis Proteins R&D Research & development Tuberculosis Tuberculosis Vaccines - immunology Vaccination Vaccines Veterinary medicine
Online-Zugang:	Volltext
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