Phosphorylation of mitogen- and stress-activated protein kinase-1 in astrocytic inflammation: a possible role in inhibiting production of inflammatory cytokines

It is generally accepted that inflammation has a role in the progression of many central nervous system (CNS) diseases, although the mechanisms through which this occurs remain unclear. Among mitogen-activated protein kinase (MAPK) targets, mitogen- and stress-activated protein kinase (MSK1) has bee...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e81747
Hauptverfasser:	Gong, Peipei, Xu, Xide, Shi, Jinlong, Ni, Lanchun, Huang, Qingfeng, Xia, Liang, Nie, Dekang, Lu, Xiaojian, Chen, Jian, Shi, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Astrocytes Astrocytes - metabolism Astrocytes - pathology Bacteria Brain Brain injuries Brain Injuries - chemically induced Brain Injuries - genetics Brain Injuries - metabolism Brain Injuries - pathology Brain injury Central nervous system Cerebral cortex Cerebral Cortex - metabolism Cerebral Cortex - pathology Cytokines Disease Enzyme-linked immunosorbent assay Enzymes Gene expression Gene Expression Regulation Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Head injuries Hospitals Immunofluorescence Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - pathology Injections, Intraventricular Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Intermediate filament proteins Kinases Laboratories Lipopolysaccharides Male MAP kinase Medical research Mitogens Mutation Nervous system Neurodegeneration Neurosurgery Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Phosphorylation Primary Cell Culture Protein kinases Proteins Rats Rats, Sprague-Dawley Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors Ribosomal Protein S6 Kinases, 90-kDa - genetics Ribosomal Protein S6 Kinases, 90-kDa - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Signal Transduction Signaling siRNA Synthesis Traumatic brain injury Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Ventricle (lateral)
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