Effects of sustained sleep restriction on mitogen-stimulated cytokines, chemokines and T helper 1/ T helper 2 balance in humans

Recent studies suggest that acute sleep deprivation disrupts cellular immune responses by shifting T helper (Th) cell activity towards a Th2 cytokine profile. Since little is known about more long-term effects, we investigated how five days of sleep restriction would affect pro-inflammatory, chemota...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e82291
Hauptverfasser:	Axelsson, John, Rehman, Javaid-ur, Akerstedt, Torbjorn, Ekman, Rolf, Miller, Gregory E, Höglund, Caroline Olgart, Lekander, Mats
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol Analysis ASTHMA CELLS Chemokines Chemokines - biosynthesis Chemokines - immunology Chronic obstructive pulmonary disease CORTISOL Cytokines DEPRIVATION DISEASE DURATION Glucocorticoids Growth hormones GROWTH-HORMONE Humans Hydrocortisone - metabolism Immune response Immune response (cell-mediated) IMMUNE-RESPONSES INFLAMMATION Integrative medicine Interleukin 2 Interleukin 4 Interleukins Laboratories Leukocyte Count Leukocytes Leukocytes (mononuclear) Long-term effects Lymphocytes T Male Males Medicin och hälsovetenskap Medicine Mitogens Mitogens - immunology Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Neurosciences Neurovetenskaper Physiology Phytohemagglutinins - immunology PROLACTIN Psychological stress Sleep Sleep and wakefulness Sleep deprivation Sleep Deprivation - immunology Stress (Psychology) Studies Th1 Cells - drug effects Th1 Cells - immunology Th1-Th2 Balance Th2 Cells - drug effects Th2 Cells - immunology Tumor necrosis factor-α Young Adult
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