PI3K/Akt signal pathway involved in the cognitive impairment caused by chronic cerebral hypoperfusion in rats

Chronic cerebral hypoperfusion (CCH) is a common pathophysiological state that usually occurs in conditions such as vascular dementia and Alzheimer's disease, both of which are characterized by cognitive impairment. In previous studies we found that learning capacity and memory were gradually i...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e81901-e81901
Hauptverfasser:	Shu, Yi, Zhang, Hong, Kang, Tao, Zhang, Jun-jian, Yang, Ying, Liu, Hui, Zhang, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Alzheimer's disease Animal cognition Animals Arteries Aspartate Brain Brain-derived neurotrophic factor Carotid arteries Carotid artery Cerebral blood flow Cerebrovascular Circulation Cerebrovascular Disorders - metabolism Cerebrovascular Disorders - pathology Cerebrovascular Disorders - psychology Cognition Cognitive ability Cyclic AMP response element-binding protein Dementia Dementia disorders Glutamic acid receptors Hospitals Impairment Insulin Insulin-like growth factors Ischemia Kinases Laboratory animals Learning Male Maze Learning Memory N-Methyl-D-aspartic acid receptors Nerve growth factor Neurodegenerative diseases Neurology Occlusion Pathogenesis Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein binding Protein kinases Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Rodents Signal Transduction Stroke Studies Surgery Swimming Synaptophysin Tau protein Vascular dementia Veins & arteries Western blotting
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