Does an isoniazid prophylaxis register improve tuberculosis contact management in South African children?
We compared the change in child household contact management of pulmonary tuberculosis (TB) cases before and after the implementation of an isoniazid preventive therapy (IPT) register in an urban clinic setting in Cape Town, South Africa. We determined if the presence of an IPT register was associat...
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| Veröffentlicht in: | PloS one 2013-12, Vol.8 (12), p.e80803-e80803 |
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| creator | van Soelen, Nelda du Preez, Karen van Wyk, Susan S Mandalakas, Anna M Enarson, Don A Reid, Anthony J Hesseling, Anneke C |
| description | We compared the change in child household contact management of pulmonary tuberculosis (TB) cases before and after the implementation of an isoniazid preventive therapy (IPT) register in an urban clinic setting in Cape Town, South Africa.
We determined if the presence of an IPT register was associated with an increase in the number of child contacts identified per infectious case and the proportion of identified children who were started on IPT.
We reviewed routine programme data on IPT delivery to children during two time periods (May 2008-October 2008 and May 2011-October 2011), before and after the implementation of an IPT register used by routine clinic personnel.
Adult TB case demographic and clinical characteristics from the two observation periods were similar. During the post-register period, more child contacts per adult case were identified (0.7 (54 children) vs. 0.3 (24 children)), more of the identified children were started on IPT (54 vs. 4) and 37% of those who started, completed six months of treatment compared to the pre-register period where no adherence information was recorded.
After pilot implementation of an IPT register, documented identification of child contacts, IPT initiation and IPT adherence documentation in TB exposed children was improved. Our findings support further exploration of the potential impact of using standardised IPT recording and reporting in routine clinics in high-burden TB settings to improve TB prevention efforts targeted at young children. Future efforts to improve IPT delivery should be systematic and comprehensive in order to support a change in current operational IPT delivery practices in TB programs. |
| doi_str_mv | 10.1371/journal.pone.0080803 |
| format | Article |
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We determined if the presence of an IPT register was associated with an increase in the number of child contacts identified per infectious case and the proportion of identified children who were started on IPT.
We reviewed routine programme data on IPT delivery to children during two time periods (May 2008-October 2008 and May 2011-October 2011), before and after the implementation of an IPT register used by routine clinic personnel.
Adult TB case demographic and clinical characteristics from the two observation periods were similar. During the post-register period, more child contacts per adult case were identified (0.7 (54 children) vs. 0.3 (24 children)), more of the identified children were started on IPT (54 vs. 4) and 37% of those who started, completed six months of treatment compared to the pre-register period where no adherence information was recorded.
After pilot implementation of an IPT register, documented identification of child contacts, IPT initiation and IPT adherence documentation in TB exposed children was improved. Our findings support further exploration of the potential impact of using standardised IPT recording and reporting in routine clinics in high-burden TB settings to improve TB prevention efforts targeted at young children. Future efforts to improve IPT delivery should be systematic and comprehensive in order to support a change in current operational IPT delivery practices in TB programs.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0080803</identifier><identifier>PMID: 24339884</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Child ; Children ; Children & youth ; Childrens health ; Demographics ; Disease prevention ; Drug therapy ; Epidemiology ; Female ; Health sciences ; Health services ; Households ; Housing - statistics & numerical data ; Humans ; Isoniazid ; Isoniazid - pharmacology ; Lung diseases ; Male ; Medical diagnosis ; Medicine ; Pediatrics ; Preventive medicine ; Prophylaxis ; Public health ; Registries ; Reviews ; South Africa - epidemiology ; Studies ; Tuberculosis ; Tuberculosis, Pulmonary - epidemiology ; Tuberculosis, Pulmonary - prevention & control ; Tuberculosis, Pulmonary - transmission ; Tutu, Desmond</subject><ispartof>PloS one, 2013-12, Vol.8 (12), p.e80803-e80803</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 van Soelen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/3.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 van Soelen et al 2013 van Soelen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2d3936aae80a403d5b4c84d96b6ef2758c000afd516c682f7c22e51756e47fa03</citedby><cites>FETCH-LOGICAL-c692t-2d3936aae80a403d5b4c84d96b6ef2758c000afd516c682f7c22e51756e47fa03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858233/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858233/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24339884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Soelen, Nelda</creatorcontrib><creatorcontrib>du Preez, Karen</creatorcontrib><creatorcontrib>van Wyk, Susan S</creatorcontrib><creatorcontrib>Mandalakas, Anna M</creatorcontrib><creatorcontrib>Enarson, Don A</creatorcontrib><creatorcontrib>Reid, Anthony J</creatorcontrib><creatorcontrib>Hesseling, Anneke C</creatorcontrib><title>Does an isoniazid prophylaxis register improve tuberculosis contact management in South African children?</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We compared the change in child household contact management of pulmonary tuberculosis (TB) cases before and after the implementation of an isoniazid preventive therapy (IPT) register in an urban clinic setting in Cape Town, South Africa.
We determined if the presence of an IPT register was associated with an increase in the number of child contacts identified per infectious case and the proportion of identified children who were started on IPT.
We reviewed routine programme data on IPT delivery to children during two time periods (May 2008-October 2008 and May 2011-October 2011), before and after the implementation of an IPT register used by routine clinic personnel.
Adult TB case demographic and clinical characteristics from the two observation periods were similar. During the post-register period, more child contacts per adult case were identified (0.7 (54 children) vs. 0.3 (24 children)), more of the identified children were started on IPT (54 vs. 4) and 37% of those who started, completed six months of treatment compared to the pre-register period where no adherence information was recorded.
After pilot implementation of an IPT register, documented identification of child contacts, IPT initiation and IPT adherence documentation in TB exposed children was improved. Our findings support further exploration of the potential impact of using standardised IPT recording and reporting in routine clinics in high-burden TB settings to improve TB prevention efforts targeted at young children. Future efforts to improve IPT delivery should be systematic and comprehensive in order to support a change in current operational IPT delivery practices in TB programs.</description><subject>Adult</subject><subject>Age</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Childrens health</subject><subject>Demographics</subject><subject>Disease prevention</subject><subject>Drug therapy</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health sciences</subject><subject>Health services</subject><subject>Households</subject><subject>Housing - statistics & numerical data</subject><subject>Humans</subject><subject>Isoniazid</subject><subject>Isoniazid - pharmacology</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Pediatrics</subject><subject>Preventive medicine</subject><subject>Prophylaxis</subject><subject>Public health</subject><subject>Registries</subject><subject>Reviews</subject><subject>South Africa - epidemiology</subject><subject>Studies</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><subject>Tuberculosis, Pulmonary - prevention & control</subject><subject>Tuberculosis, Pulmonary - transmission</subject><subject>Tutu, Desmond</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQkJw2MWxHce5gFbla6VKlShwtRxnkniV2FvbqVp-Pd5uWm1QD8gHW-Nn3vnSJMnLDC0zUmQfNnZ0RvbLrTWwRIjHQx4lx1lJ8IJhRB4fvI-SZ95vEMoJZ-xpcoQpISXn9DjRny34VJpUe2u0_KPrdOvstrvp5bX2qYNW-wAu1UM0X0EaxgqcGnvr46-yJkgV0kEa2cIAJqTapBd2DF26apxWUVd1uq8dmE_PkyeN7D28mO6T5NfXLz9Pvy_Ozr-tT1dnC8VKHBa4JiVhUgJHkiJS5xVVnNYlqxg0uMi5QgjJps4zphjHTaEwhjwrcga0aCQiJ8nrve42JimmLnmRUcZymmfljljvidrKjdg6PUh3I6zU4tZgXSukC1r1IFSteKVIxqpSUVqiCjMoKgWUKwpFyaPWxynaWA1Qq9gDJ_uZ6PzH6E609koQnnNMSBR4Nwk4ezmCD2LQXkHfSwN2vM27xBmijEb0zT_ow9VNVCtjAdo0NsZVO1GxogUnNGe0iNTyASqeGgYd5wqNjvaZw_uZw272cB1aOXov1hc__p89_z1n3x6wHcg-dN72Y9DW-DlI96By1nsHzX2TMyR2G3HXDbHbCDFtRHR7dTige6e7FSB_Aa_0B50</recordid><startdate>20131210</startdate><enddate>20131210</enddate><creator>van Soelen, Nelda</creator><creator>du Preez, Karen</creator><creator>van Wyk, Susan S</creator><creator>Mandalakas, Anna M</creator><creator>Enarson, Don A</creator><creator>Reid, Anthony J</creator><creator>Hesseling, Anneke C</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131210</creationdate><title>Does an isoniazid prophylaxis register improve tuberculosis contact management in South African children?</title><author>van Soelen, Nelda ; du Preez, Karen ; van Wyk, Susan S ; Mandalakas, Anna M ; Enarson, Don A ; Reid, Anthony J ; Hesseling, Anneke C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2d3936aae80a403d5b4c84d96b6ef2758c000afd516c682f7c22e51756e47fa03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age</topic><topic>Child</topic><topic>Children</topic><topic>Children & youth</topic><topic>Childrens health</topic><topic>Demographics</topic><topic>Disease prevention</topic><topic>Drug therapy</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health sciences</topic><topic>Health services</topic><topic>Households</topic><topic>Housing - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Soelen, Nelda</au><au>du Preez, Karen</au><au>van Wyk, Susan S</au><au>Mandalakas, Anna M</au><au>Enarson, Don A</au><au>Reid, Anthony J</au><au>Hesseling, Anneke C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does an isoniazid prophylaxis register improve tuberculosis contact management in South African children?</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-12-10</date><risdate>2013</risdate><volume>8</volume><issue>12</issue><spage>e80803</spage><epage>e80803</epage><pages>e80803-e80803</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We compared the change in child household contact management of pulmonary tuberculosis (TB) cases before and after the implementation of an isoniazid preventive therapy (IPT) register in an urban clinic setting in Cape Town, South Africa.
We determined if the presence of an IPT register was associated with an increase in the number of child contacts identified per infectious case and the proportion of identified children who were started on IPT.
We reviewed routine programme data on IPT delivery to children during two time periods (May 2008-October 2008 and May 2011-October 2011), before and after the implementation of an IPT register used by routine clinic personnel.
Adult TB case demographic and clinical characteristics from the two observation periods were similar. During the post-register period, more child contacts per adult case were identified (0.7 (54 children) vs. 0.3 (24 children)), more of the identified children were started on IPT (54 vs. 4) and 37% of those who started, completed six months of treatment compared to the pre-register period where no adherence information was recorded.
After pilot implementation of an IPT register, documented identification of child contacts, IPT initiation and IPT adherence documentation in TB exposed children was improved. Our findings support further exploration of the potential impact of using standardised IPT recording and reporting in routine clinics in high-burden TB settings to improve TB prevention efforts targeted at young children. Future efforts to improve IPT delivery should be systematic and comprehensive in order to support a change in current operational IPT delivery practices in TB programs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24339884</pmid><doi>10.1371/journal.pone.0080803</doi><tpages>e80803</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Child Children Children & youth Childrens health Demographics Disease prevention Drug therapy Epidemiology Female Health sciences Health services Households Housing - statistics & numerical data Humans Isoniazid Isoniazid - pharmacology Lung diseases Male Medical diagnosis Medicine Pediatrics Preventive medicine Prophylaxis Public health Registries Reviews South Africa - epidemiology Studies Tuberculosis Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - prevention & control Tuberculosis, Pulmonary - transmission Tutu, Desmond |
| title | Does an isoniazid prophylaxis register improve tuberculosis contact management in South African children? |
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