Beauvericin ameliorates experimental colitis by inhibiting activated T cells via downregulation of the PI3K/Akt signaling pathway

Crohn's disease is a common, chronic inflammatory bowel condition characterized by remission and relapse. Accumulating evidence indicates that activated T cells play an important role in this disease. In the present study, we aimed to examine the effect of beauvericin, a natural cyclic peptide,...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e83013
Hauptverfasser:	Wu, Xue-Feng, Xu, Rui, Ouyang, Zi-Jun, Qian, Cheng, Shen, Yan, Wu, Xu-Dong, Gu, Yan-Hong, Xu, Qiang, Sun, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Apoptosis Bcl-2 protein Beauvericin Biological response modifiers Caspase Caspase-3 Cell activation Cell proliferation Cell Proliferation - drug effects Cell survival Colitis Colitis - chemically induced Colitis - drug therapy Crohn's disease Cytometry Depsipeptides - therapeutic use Development and progression Diarrhea Disease Models, Animal Down-Regulation Female Flow Cytometry Gene Expression Regulation, Enzymologic Health aspects Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inhibition Interferon Interferon-gamma - metabolism Intestine Kinases Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred BALB C Pharmaceuticals Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Poly(ADP-ribose) polymerase Proto-Oncogene Proteins c-akt - metabolism Remission Serum levels Signal Transduction Signaling Stat1 protein Sulfonic acid T cells T-Lymphocytes - drug effects Trinitrobenzenesulfonic Acid - chemistry Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Weight reduction γ-Interferon
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