An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina

In the outer retina, G protein-coupled receptor (GPCR) signaling mediates phototransduction and synaptic transmission between photoreceptors and ON bipolar cells. In contrast, the functions of modulatory GPCR signaling networks in the inner retina are less well understood. We addressed this question...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e82276
Hauptverfasser:	Cain, Matthew D, Vo, Bradly Q, Kolesnikov, Alexander V, Kefalov, Vladimir J, Culican, Susan M, Kerschensteiner, Daniel, Blumer, Kendall J
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - radiation effects Acuity Allosteric properties Allosteric Regulation - radiation effects Amacrine cells Amacrine Cells - metabolism Amacrine Cells - radiation effects Analysis Animals Animals, Newborn Bipolar cells Brain research Choline - metabolism Cones Contrast Sensitivity - radiation effects Deactivation Electroretinography Firing rate G protein-coupled receptors G proteins Gene Deletion Glutamatergic transmission Glutamates - metabolism Immunoglobulins Laboratories Latency Lateral geniculate nucleus Light Medicine Membrane proteins Mice Mice, Inbred C57BL Neurosciences Photoreceptors Phototransduction Physiology Protein binding Proteins Reflexes Retina Retina - metabolism Retina - radiation effects Retinal Bipolar Cells - metabolism Retinal Bipolar Cells - radiation effects Retinal Cone Photoreceptor Cells - metabolism Retinal ganglion cells Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - radiation effects Retinal Rod Photoreceptor Cells - metabolism RGS Proteins - deficiency RGS Proteins - metabolism Rods Sensitivity analysis Signal transduction Signaling Synaptic transmission Transcription Factor Brn-3A - metabolism Transmitters Visual acuity Visual Acuity - radiation effects
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