Risk of obstructive sleep apnea in Parkinson's disease: a meta-analysis
Sleep disorders are a common symptom of Parkinson's disease (PD) and they significantly impair the sleep quality of the PD patients. However, there is no conclusive evidence to support the relation between PD and the prevalence of obstructive sleep apnea (OSA). The purpose of this meta-analysis...
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| Veröffentlicht in: | PloS one 2013-12, Vol.8 (12), p.e82091-e82091 |
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| creator | Zeng, Jun Wei, Min Li, Taoping Chen, Wei Feng, Yuan Shi, Rong Song, Yanbin Zheng, Wenling Ma, Wenli |
| description | Sleep disorders are a common symptom of Parkinson's disease (PD) and they significantly impair the sleep quality of the PD patients. However, there is no conclusive evidence to support the relation between PD and the prevalence of obstructive sleep apnea (OSA). The purpose of this meta-analysis review is to evaluate the association between PD and the prevalence of OSA.
A comprehensive literature search was conducted on PubMed and Embase through July 2013. Only studies that referred to PD and the prevalence of OSA and that met the selection criteria were included in the analysis. The odds ratios (ORs) were used to evaluate the relationship of PD and the prevalence of OSA by the fixed-effect model.
Five eligible studies were analyzed in this study including 322 cases and 6,361 controls. The pooled-analysis showed the OR to be 0.60 (95% confidence interval (CI): 0.44 to 0.81, P = 0.001) and I(2) = 0.0% (χ(2) = 3.90, P = 0.420) in the fixed-effect model.
Although we only included five small sample studies that indicated high homogeneity in the heterogeneity test, the results suggest that there is a significant negative association between PD and the prevalence of OSA; PD patients generally have a reduced prevalence of OSA. According to our analysis, these results are primarily due to the lower BMI of PD patients when compared with the general population controls. |
| doi_str_mv | 10.1371/journal.pone.0082091 |
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A comprehensive literature search was conducted on PubMed and Embase through July 2013. Only studies that referred to PD and the prevalence of OSA and that met the selection criteria were included in the analysis. The odds ratios (ORs) were used to evaluate the relationship of PD and the prevalence of OSA by the fixed-effect model.
Five eligible studies were analyzed in this study including 322 cases and 6,361 controls. The pooled-analysis showed the OR to be 0.60 (95% confidence interval (CI): 0.44 to 0.81, P = 0.001) and I(2) = 0.0% (χ(2) = 3.90, P = 0.420) in the fixed-effect model.
Although we only included five small sample studies that indicated high homogeneity in the heterogeneity test, the results suggest that there is a significant negative association between PD and the prevalence of OSA; PD patients generally have a reduced prevalence of OSA. According to our analysis, these results are primarily due to the lower BMI of PD patients when compared with the general population controls.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0082091</identifier><identifier>PMID: 24349191</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Airway management ; Apnea ; Body mass ; Body mass index ; Case-Control Studies ; Confidence intervals ; Gender ; Genetic engineering ; Homogeneity ; Humans ; Medical research ; Meta-analysis ; Movement disorders ; Neurodegenerative diseases ; Parkinson Disease - complications ; Parkinson's disease ; Parkinsons disease ; Patients ; Population ; Prevalence ; Quality ; Quality Assurance, Health Care ; Restless legs syndrome ; Risk Factors ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - epidemiology ; Sleep Apnea, Obstructive - etiology ; Sleep disorders ; Studies ; Systematic review</subject><ispartof>PloS one, 2013-12, Vol.8 (12), p.e82091-e82091</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Zeng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Zeng et al 2013 Zeng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4aa8c6c48d319b96649ee91b3c32804182790ca7ed078fa290b42dbc789e7c6f3</citedby><cites>FETCH-LOGICAL-c692t-4aa8c6c48d319b96649ee91b3c32804182790ca7ed078fa290b42dbc789e7c6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857239/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857239/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24349191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yung, Wing-ho</contributor><creatorcontrib>Zeng, Jun</creatorcontrib><creatorcontrib>Wei, Min</creatorcontrib><creatorcontrib>Li, Taoping</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Feng, Yuan</creatorcontrib><creatorcontrib>Shi, Rong</creatorcontrib><creatorcontrib>Song, Yanbin</creatorcontrib><creatorcontrib>Zheng, Wenling</creatorcontrib><creatorcontrib>Ma, Wenli</creatorcontrib><title>Risk of obstructive sleep apnea in Parkinson's disease: a meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Sleep disorders are a common symptom of Parkinson's disease (PD) and they significantly impair the sleep quality of the PD patients. However, there is no conclusive evidence to support the relation between PD and the prevalence of obstructive sleep apnea (OSA). The purpose of this meta-analysis review is to evaluate the association between PD and the prevalence of OSA.
A comprehensive literature search was conducted on PubMed and Embase through July 2013. Only studies that referred to PD and the prevalence of OSA and that met the selection criteria were included in the analysis. The odds ratios (ORs) were used to evaluate the relationship of PD and the prevalence of OSA by the fixed-effect model.
Five eligible studies were analyzed in this study including 322 cases and 6,361 controls. The pooled-analysis showed the OR to be 0.60 (95% confidence interval (CI): 0.44 to 0.81, P = 0.001) and I(2) = 0.0% (χ(2) = 3.90, P = 0.420) in the fixed-effect model.
Although we only included five small sample studies that indicated high homogeneity in the heterogeneity test, the results suggest that there is a significant negative association between PD and the prevalence of OSA; PD patients generally have a reduced prevalence of OSA. According to our analysis, these results are primarily due to the lower BMI of PD patients when compared with the general population controls.</description><subject>Age</subject><subject>Airway management</subject><subject>Apnea</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Gender</subject><subject>Genetic engineering</subject><subject>Homogeneity</subject><subject>Humans</subject><subject>Medical research</subject><subject>Meta-analysis</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson's disease</subject><subject>Parkinsons disease</subject><subject>Patients</subject><subject>Population</subject><subject>Prevalence</subject><subject>Quality</subject><subject>Quality Assurance, Health Care</subject><subject>Restless legs syndrome</subject><subject>Risk Factors</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Jun</au><au>Wei, Min</au><au>Li, Taoping</au><au>Chen, Wei</au><au>Feng, Yuan</au><au>Shi, Rong</au><au>Song, Yanbin</au><au>Zheng, Wenling</au><au>Ma, Wenli</au><au>Yung, Wing-ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of obstructive sleep apnea in Parkinson's disease: a meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-12-09</date><risdate>2013</risdate><volume>8</volume><issue>12</issue><spage>e82091</spage><epage>e82091</epage><pages>e82091-e82091</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Sleep disorders are a common symptom of Parkinson's disease (PD) and they significantly impair the sleep quality of the PD patients. However, there is no conclusive evidence to support the relation between PD and the prevalence of obstructive sleep apnea (OSA). The purpose of this meta-analysis review is to evaluate the association between PD and the prevalence of OSA.
A comprehensive literature search was conducted on PubMed and Embase through July 2013. Only studies that referred to PD and the prevalence of OSA and that met the selection criteria were included in the analysis. The odds ratios (ORs) were used to evaluate the relationship of PD and the prevalence of OSA by the fixed-effect model.
Five eligible studies were analyzed in this study including 322 cases and 6,361 controls. The pooled-analysis showed the OR to be 0.60 (95% confidence interval (CI): 0.44 to 0.81, P = 0.001) and I(2) = 0.0% (χ(2) = 3.90, P = 0.420) in the fixed-effect model.
Although we only included five small sample studies that indicated high homogeneity in the heterogeneity test, the results suggest that there is a significant negative association between PD and the prevalence of OSA; PD patients generally have a reduced prevalence of OSA. According to our analysis, these results are primarily due to the lower BMI of PD patients when compared with the general population controls.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24349191</pmid><doi>10.1371/journal.pone.0082091</doi><tpages>e82091</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Airway management Apnea Body mass Body mass index Case-Control Studies Confidence intervals Gender Genetic engineering Homogeneity Humans Medical research Meta-analysis Movement disorders Neurodegenerative diseases Parkinson Disease - complications Parkinson's disease Parkinsons disease Patients Population Prevalence Quality Quality Assurance, Health Care Restless legs syndrome Risk Factors Sleep Sleep apnea Sleep Apnea, Obstructive - epidemiology Sleep Apnea, Obstructive - etiology Sleep disorders Studies Systematic review |
| title | Risk of obstructive sleep apnea in Parkinson's disease: a meta-analysis |
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