A randomised placebo-controlled trial to differentiate the acute cognitive and mood effects of chlorogenic acid from decaffeinated coffee
In the current study, sixty healthy older adults aged 50 years or older, and who were light to moderate coffee drinkers, were administered 6g of a decaffeinated green coffee blend (NESCAFÉ Green Blend coffee; GB) or 540mg pure chlorogenic acids (CGA) or placebo in a double-blind acute cross-over des...
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| description | In the current study, sixty healthy older adults aged 50 years or older, and who were light to moderate coffee drinkers, were administered 6g of a decaffeinated green coffee blend (NESCAFÉ Green Blend coffee; GB) or 540mg pure chlorogenic acids (CGA) or placebo in a double-blind acute cross-over design, with cognitive and mood assessments pre-dose, 40-mins and 120-mins post-dose. The primary outcome measure was accuracy in Rapid Visual Information Processing (RVIP). Secondary cognitive outcome measures included RVIP reaction time as well as Inspection time (IT), Jensen Box decision/reaction times, serial subtraction and N-Back working memory. Secondary mood measures included Bond-Lader and caffeine Research visual analogue scales (VAS). No significant treatment effects were found for the primary outcome measure, although significant effects were found amongst secondary measures. Overall, CGA in isolation was not found to significantly improve cognitive function relative to placebo whereas the GB was found to improve sustained attention as measured by the N-Back task in comparison to placebo overall (t=2.45,p=.05), as well as decision time on a 2-choice reaction time task (Jensen box) in comparison to placebo at 40 minutes post-dose (t=2.45,p=.05). Similarly, GB was found to improve alertness on both the Bond-Lader at 120 minutes relative to CGA (t=2.86, p=0.02) and the caffeine Research VAS relative to CGA (t=3.09, p=0.009) and placebo (t=2.75,p=0.02) at 120 minutes post-dose. Both the GB and CGA were also found to significantly improve symptoms of headache at 120 minutes relative to placebo (t=2.51,p=0.03 and t=2.43,p=.04 respectively), whilst there was a trend towards a reduction in jitteriness with GB and CGA in comparison to placebo at 40 minutes post-dose (t=2.24,p=0.06 and t=2.20,p=0.06 respectively). These findings suggest that the improvements in mood observed with GB, but not the improvements in cognitive function, are likely to some extent to be attributable to CGAs.
Australia New Zealand Clinical Trials Registry ACTRN12611000067976 www.anzctr.org.au. |
| doi_str_mv | 10.1371/journal.pone.0082897 |
| format | Article |
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Australia New Zealand Clinical Trials Registry ACTRN12611000067976 www.anzctr.org.au.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0082897</identifier><identifier>PMID: 24349389</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accuracy ; Acids ; Adult ; Adults ; Affect - drug effects ; Aged ; Alertness ; Analysis ; Animal cognition ; Attention - drug effects ; Caffeine ; Chlorogenic acid ; Chlorogenic Acid - administration & dosage ; Chlorogenic Acid - chemistry ; Clinical trials ; Coffee ; Coffee - chemistry ; Cognition - drug effects ; Cognitive ability ; Cross-Over Studies ; Data processing ; Double-Blind Method ; Female ; Food ; Headache ; Headache - drug therapy ; Humans ; Information processing ; Inspection ; Laboratories ; Male ; Medical research ; Middle Aged ; Mood ; Older people ; Physiology ; Phytochemicals ; Psychopharmacology ; Reaction time ; Reaction time task ; Short term memory ; Subtraction ; Time Factors ; Vaccinium angustifolium</subject><ispartof>PloS one, 2013-12, Vol.8 (12), p.e82897-e82897</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Camfield et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Camfield et al 2013 Camfield et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-56f6accea0c1db3b36a4206c30bb5bc3bfb74b9819426df9020678da97ee26853</citedby><cites>FETCH-LOGICAL-c692t-56f6accea0c1db3b36a4206c30bb5bc3bfb74b9819426df9020678da97ee26853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857311/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857311/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24349389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camfield, David A</creatorcontrib><creatorcontrib>Silber, Beata Y</creatorcontrib><creatorcontrib>Scholey, Andrew B</creatorcontrib><creatorcontrib>Nolidin, Karen</creatorcontrib><creatorcontrib>Goh, Antionette</creatorcontrib><creatorcontrib>Stough, Con</creatorcontrib><title>A randomised placebo-controlled trial to differentiate the acute cognitive and mood effects of chlorogenic acid from decaffeinated coffee</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In the current study, sixty healthy older adults aged 50 years or older, and who were light to moderate coffee drinkers, were administered 6g of a decaffeinated green coffee blend (NESCAFÉ Green Blend coffee; GB) or 540mg pure chlorogenic acids (CGA) or placebo in a double-blind acute cross-over design, with cognitive and mood assessments pre-dose, 40-mins and 120-mins post-dose. The primary outcome measure was accuracy in Rapid Visual Information Processing (RVIP). Secondary cognitive outcome measures included RVIP reaction time as well as Inspection time (IT), Jensen Box decision/reaction times, serial subtraction and N-Back working memory. Secondary mood measures included Bond-Lader and caffeine Research visual analogue scales (VAS). No significant treatment effects were found for the primary outcome measure, although significant effects were found amongst secondary measures. Overall, CGA in isolation was not found to significantly improve cognitive function relative to placebo whereas the GB was found to improve sustained attention as measured by the N-Back task in comparison to placebo overall (t=2.45,p=.05), as well as decision time on a 2-choice reaction time task (Jensen box) in comparison to placebo at 40 minutes post-dose (t=2.45,p=.05). Similarly, GB was found to improve alertness on both the Bond-Lader at 120 minutes relative to CGA (t=2.86, p=0.02) and the caffeine Research VAS relative to CGA (t=3.09, p=0.009) and placebo (t=2.75,p=0.02) at 120 minutes post-dose. Both the GB and CGA were also found to significantly improve symptoms of headache at 120 minutes relative to placebo (t=2.51,p=0.03 and t=2.43,p=.04 respectively), whilst there was a trend towards a reduction in jitteriness with GB and CGA in comparison to placebo at 40 minutes post-dose (t=2.24,p=0.06 and t=2.20,p=0.06 respectively). These findings suggest that the improvements in mood observed with GB, but not the improvements in cognitive function, are likely to some extent to be attributable to CGAs.
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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camfield, David A</au><au>Silber, Beata Y</au><au>Scholey, Andrew B</au><au>Nolidin, Karen</au><au>Goh, Antionette</au><au>Stough, Con</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A randomised placebo-controlled trial to differentiate the acute cognitive and mood effects of chlorogenic acid from decaffeinated coffee</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-12-09</date><risdate>2013</risdate><volume>8</volume><issue>12</issue><spage>e82897</spage><epage>e82897</epage><pages>e82897-e82897</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In the current study, sixty healthy older adults aged 50 years or older, and who were light to moderate coffee drinkers, were administered 6g of a decaffeinated green coffee blend (NESCAFÉ Green Blend coffee; GB) or 540mg pure chlorogenic acids (CGA) or placebo in a double-blind acute cross-over design, with cognitive and mood assessments pre-dose, 40-mins and 120-mins post-dose. The primary outcome measure was accuracy in Rapid Visual Information Processing (RVIP). Secondary cognitive outcome measures included RVIP reaction time as well as Inspection time (IT), Jensen Box decision/reaction times, serial subtraction and N-Back working memory. Secondary mood measures included Bond-Lader and caffeine Research visual analogue scales (VAS). No significant treatment effects were found for the primary outcome measure, although significant effects were found amongst secondary measures. Overall, CGA in isolation was not found to significantly improve cognitive function relative to placebo whereas the GB was found to improve sustained attention as measured by the N-Back task in comparison to placebo overall (t=2.45,p=.05), as well as decision time on a 2-choice reaction time task (Jensen box) in comparison to placebo at 40 minutes post-dose (t=2.45,p=.05). Similarly, GB was found to improve alertness on both the Bond-Lader at 120 minutes relative to CGA (t=2.86, p=0.02) and the caffeine Research VAS relative to CGA (t=3.09, p=0.009) and placebo (t=2.75,p=0.02) at 120 minutes post-dose. Both the GB and CGA were also found to significantly improve symptoms of headache at 120 minutes relative to placebo (t=2.51,p=0.03 and t=2.43,p=.04 respectively), whilst there was a trend towards a reduction in jitteriness with GB and CGA in comparison to placebo at 40 minutes post-dose (t=2.24,p=0.06 and t=2.20,p=0.06 respectively). These findings suggest that the improvements in mood observed with GB, but not the improvements in cognitive function, are likely to some extent to be attributable to CGAs.
Australia New Zealand Clinical Trials Registry ACTRN12611000067976 www.anzctr.org.au.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24349389</pmid><doi>10.1371/journal.pone.0082897</doi><tpages>e82897</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1466172529 |
| source | MEDLINE; Public Library of Science; Full-Text Journals in Chemistry (Open access); DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Accuracy Acids Adult Adults Affect - drug effects Aged Alertness Analysis Animal cognition Attention - drug effects Caffeine Chlorogenic acid Chlorogenic Acid - administration & dosage Chlorogenic Acid - chemistry Clinical trials Coffee Coffee - chemistry Cognition - drug effects Cognitive ability Cross-Over Studies Data processing Double-Blind Method Female Food Headache Headache - drug therapy Humans Information processing Inspection Laboratories Male Medical research Middle Aged Mood Older people Physiology Phytochemicals Psychopharmacology Reaction time Reaction time task Short term memory Subtraction Time Factors Vaccinium angustifolium |
| title | A randomised placebo-controlled trial to differentiate the acute cognitive and mood effects of chlorogenic acid from decaffeinated coffee |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T17%3A04%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20randomised%20placebo-controlled%20trial%20to%20differentiate%20the%20acute%20cognitive%20and%20mood%20effects%20of%20chlorogenic%20acid%20from%20decaffeinated%20coffee&rft.jtitle=PloS%20one&rft.au=Camfield,%20David%20A&rft.date=2013-12-09&rft.volume=8&rft.issue=12&rft.spage=e82897&rft.epage=e82897&rft.pages=e82897-e82897&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0082897&rft_dat=%3Cgale_plos_%3EA478358322%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1466172529&rft_id=info:pmid/24349389&rft_galeid=A478358322&rft_doaj_id=oai_doaj_org_article_ef1cad035ca34338900386678e6a0aef&rfr_iscdi=true |