Impact of perinatal systemic hypoxic-ischemic injury on the brain of male offspring rats: an improved model of neonatal hypoxic-ischemic encephalopathy in early preterm newborns

In this study, we attempted to design a model using Sprague-Dawley rats to better reproduce perinatal systemic hypoxic-ischemic encephalopathy (HIE) in early preterm newborns. On day 21 of gestation, the uterus of pregnant rats were exposed and the blood supply to the fetuses of neonatal HIE groups...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e82502-e82502
Hauptverfasser:	Huang, Yuejun, Lai, Huihong, Xu, Hongwu, Wu, Weizhao, Lai, Xiulan, Ho, Guyu, Chen, Yunbin, Ma, Lian
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animal cognition Animals Animals, Newborn Apoptosis Brain Brain - metabolism Brain - pathology Brain damage Brain injury Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Breathing Caspase Caspase 3 - metabolism Caspase-3 Disease Models, Animal Encephalopathy Female Fetuses Genetic crosses Gestation Hippocampus - metabolism Hypoxia Hypoxia-Ischemia, Brain - metabolism Hypoxia-Ischemia, Brain - mortality Hypoxia-Ischemia, Brain - pathology Ischemia Laboratory animals Male Maternal & child health Maze Learning Medical research Memory Neonates Neurons Neurons - metabolism Neurosciences Newborn babies Offspring Pediatrics Pregnancy Premature Birth Rats Rodents Therapeutic applications Traumatic brain injury Uterus
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