Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)

P-glycoprotein (Pgp, ABCB1) is an ATP-Binding Cassette (ABC) transporter that is associated with the development of multidrug resistance in cancer cells. Pgp transports a variety of chemically dissimilar amphipathic compounds using the energy from ATP hydrolysis. In the present study, to elucidate t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e82463
Hauptverfasser:	Chufan, Eduardo E, Kapoor, Khyati, Sim, Hong-May, Singh, Satyakam, Talele, Tanaji T, Durell, Stewart R, Ambudkar, Suresh V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adenosine Triphosphate - metabolism Analysis ATP ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Baculovirus Binding Sites Biochemistry Biology Cancer Cell Line, Tumor Cell surface Cells (Biology) Cyclosporins Cysteine Docking Drugs Energy consumption Fluorescence Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Gene Expression Glycoproteins Health sciences HeLa Cells Homology Humans Hydrolysis Insects Laboratories Mammalian cells Medical research Microbial drug resistance Modelling Models, Molecular Modulators Molecular Docking Simulation Molecular modelling Multidrug resistance Mutagenesis Mutagenesis, Site-Directed Mutants Mutation P-Glycoprotein Peptides Pharmaceutical sciences Pharmacy Protein Binding Protein Conformation Protein Interaction Domains and Motifs Proteins Residues Site-directed mutagenesis Substrates Transduction, Genetic Transmembrane domains Transport Valinomycin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!