PADI2 is significantly associated with rheumatoid arthritis

Citrullination, a posttranslational modification of peptidyl arginine to citrulline, plays an essential role in rheumatoid arthritis (RA). Citrullination is catalyzed by a group of peptidylarginine deiminases (PADs) including PADI 1, 2, 3, 4 and 6. Many studies have indicated that the gene encoding...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e81259-e81259
Hauptverfasser:	Chang, Xiaotian, Xia, Yifang, Pan, Jihong, Meng, Qingsong, Zhao, Yan, Yan, Xinfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Ankylosing spondylitis Arginine Arthritis Arthritis, Rheumatoid - enzymology Arthritis, Rheumatoid - genetics Biocompatibility Biomedical materials Citrulline Consortia DNA microarrays Female Gene expression Gene Expression Regulation, Enzymologic Genes Genetic Loci - genetics Genetic Predisposition to Disease - genetics Genomes Genotyping Genotyping Techniques Haplotypes Humans Hydrolases - genetics Kinases Loci Male Medical research Middle Aged Osteoarthritis Pathogenesis Patients Peripheral blood Polymorphism, Single Nucleotide Protein-arginine deiminase Protein-Arginine Deiminases Proteins Rheumatoid arthritis Rheumatoid factor Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Spondylitis Studies Synovial Membrane - metabolism Tissues
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