Extra cellular matrix derived metabolite regulates angiogenesis by FasL mediated apoptosis

Antiangiogenic treatments are beginning to give promising outcomes in many vascular diseases including tumor angiogenesis. In this current study the antiangiogenic and pro-apoptotic actions of α1(IV)NC1 and its N- and C- peptides α1S1(IV)NC1, α1S2(IV)NC1 were investigated in-vitro and in-vivo. Endot...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e80555
Hauptverfasser:	Verma, Raj K, Gunda, Venugopal, Pawar, Smita C, Sudhakar, Yakkanti Akul
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Angiogenesis Angiogenesis Inhibitors - pharmacology Animals Antiangiogenics Antibodies Anticancer properties Antitumor activity Apoptosis Apoptosis - drug effects Cancer Caspase Caspase 3 - genetics Caspase 3 - metabolism Caspase 8 - genetics Caspase 8 - metabolism Caspase-3 Caspase-8 Cell adhesion & migration Cell Adhesion - drug effects Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cloning Collagen Collagen Type IV - pharmacology Diabetic retinopathy Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Fas Ligand Protein - agonists Fas Ligand Protein - genetics Fas Ligand Protein - metabolism fas Receptor - genetics fas Receptor - metabolism FasL protein Gene Expression Regulation, Neoplastic Humans Immunoblotting Kinases Laboratories Macular degeneration Medical research Metabolites Mice Microvasculature Neovascularization, Pathologic Penicillin Peptides Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Protein Isoforms - pharmacology Proteins Rodents Signal Transduction Skin Neoplasms - blood supply Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - pathology Studies Teratocarcinoma - blood supply Teratocarcinoma - drug therapy Teratocarcinoma - genetics Teratocarcinoma - pathology Tumors Vascular diseases Vascular endothelial growth factor
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