Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-κB pathway and attenuating ROS production

Numerous studies have reported that inflammatory cytokines are important mediators for osteoclastogenesis, thereby causing excessive bone resorption and osteoporosis. Acteoside, the main active compound of Rehmannia glutinosa, which is used widely in traditional Oriental medicine, has anti-inflammat...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e80873-e80873
Hauptverfasser:	Lee, Seung-Youp, Lee, Keun-Soo, Yi, Sea Hyun, Kook, Sung-Ho, Lee, Jeong-Chae
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Antioxidants Antioxidants - pharmacology Arthritis Biocompatibility Bone growth Bone loss Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone resorption Bone Resorption - prevention & control c-Fos protein c-Jun protein Cell Differentiation Cell Survival - drug effects Cytokines Dentistry Differentiation Female Gene Expression Regulation Glucosides - pharmacology Inflammation Interleukin Interleukin 6 Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - biosynthesis Interleukin-6 - antagonists & inhibitors Interleukin-6 - biosynthesis JNK protein Kinases Laboratory animals Ligands Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Medicine Mice Mice, Inbred ICR NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein NFATC Transcription Factors - antagonists & inhibitors NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism Orthodontics Osteoclastogenesis Osteoclasts Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteoporosis Osteoprogenitor cells Ovariectomy p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology Phenols - pharmacology Phosphorylation Proto-Oncogene Proteins c-fos - antagonists & inhibitors Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism RANK Ligand - antagonists & inhibitors RANK Ligand - genetics RANK Ligand - metabolism Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Signal Transduction Stem cells TRANCE protein Transcription factors Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis factor-TNF Tumor necrosis factor-α
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