Impact of simulated microgravity on oligodendrocyte development: implications for central nervous system repair

We have recently established a culture system to study the impact of simulated microgravity on oligodendrocyte progenitor cells (OPCs) development. We subjected mouse and human OPCs to a short exposure of simulated microgravity produced by a 3D-Clinostat robot. Our results demonstrate that rodent an...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e76963-e76963
Hauptverfasser:	Espinosa-Jeffrey, Araceli, Paez, Pablo M, Cheli, Veronica T, Spreuer, Vilma, Wanner, Ina, de Vellis, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antigens - genetics Antigens - metabolism Apoptosis Biomarkers - metabolism Bone marrow Brain research Cell culture Cell cycle Cell Cycle - genetics Cell Differentiation Cell Movement Cells (biology) Central Nervous System Cycle time Demyelination Developmental disabilities Gene Expression Glial stem cells Gravitation Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Laboratory animals Markers Medicine Mice Microgravity Myelin Basic Protein - genetics Myelin Basic Protein - metabolism Nerve Regeneration Nervous system Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurosciences Oligodendroglia - cytology Oligodendroglia - metabolism Pathology Pharmacology Primary Cell Culture Proteoglycans - genetics Proteoglycans - metabolism Robots Rodents Simulation SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem cells Time Factors Toxicology Weightlessness
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