The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice

Thyroid hormones (TH) regulate cholesterol metabolism but their use as lipid-lowering drugs is restricted due to negative cardiac effects. TH mimetic compounds modulating TH receptor β (THRβ) have been designed as potential drugs, reducing serum cholesterol levels while avoiding apparent deleterious...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e78534
Hauptverfasser:	Mörk, Lisa-Mari, Rehnmark, Stefan, Davoodpour, Padideh, Norata, Giuseppe Danilo, Larsson, Lilian, Witt, Michael-Robin, Malm, Johan, Parini, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anticholesteremic agents Anticholesteremic Agents - chemical synthesis Anticholesteremic Agents - pharmacology Aorta Apolipoprotein E Apolipoproteins Apolipoproteins B - metabolism Apolipoproteins E - deficiency Apolipoproteins E - genetics Arteriosclerosis Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - metabolism Atherosclerosis - pathology Atorvastatin Bile Acids and Salts - metabolism Biological response modifiers Biological Transport - drug effects Blood lipids Cholesterol Coronary vessels Cytokines - biosynthesis Cytokines - metabolism Diet Disease Models, Animal Drug Synergism Drugs Excretion Feces Feces - chemistry Gastroenterology Heart Heart diseases Heptanoic Acids - pharmacology Hormones Inflammation Inflammatory response Interferon Interleukin 6 Laboratories Ligands Lipid metabolism Lipids Lipoproteins Liver Low density lipoprotein receptors Macrophage colony-stimulating factor Macrophages Male Medicin och hälsovetenskap Medicine Metabolism Mice Mice, Knockout Mimetic compounds Molecular Mimicry Monocyte chemoattractant protein 1 Pharmaceuticals Physiological aspects Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Plaque, Atherosclerotic - prevention & control Plaques Pyrroles - pharmacology Rodents Serum levels Skin Statins Sterols Synergistic effect Thyroid Thyroid gland Thyroid hormones Thyroid Hormones - chemistry Triglycerides
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