Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis

Pancreatic fibrosis, a prominent histopathological feature of chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma, is essentially a dynamic process that leads to irreversible scarring of parenchymal tissues of the pancreas. Though the exact mechanisms of its initiation and development are...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e82201
Hauptverfasser:	Tsang, Siu Wai, Zhang, Hongjie, Lin, Chengyuan, Xiao, Haitao, Wong, Michael, Shang, Hongcai, Yang, Zhi-Jun, Lu, Aiping, Yung, Ken Kin-Lam, Bian, Zhaoxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Activation Adenocarcinoma Analysis Animal models Animal tissues Animals Anthraquinone Anthraquinones - therapeutic use Anti-inflammatory agents Antiinflammatory agents Attenuation Blotting, Western Care and treatment Cell Line Cell Survival - drug effects Chinese medicine Collagen (type I) Complications and side effects Development and progression Edema Extracellular matrix Fibronectin Fibronectins Fibronectins - metabolism Fibrosis Fibrosis - drug therapy Genotype & phenotype Growth factors Hedgehog protein Inflammation Liver Male Metastasis Mice Mice, Inbred C57BL Muscles Pancreas Pancreatic Diseases Pancreatic Stellate Cells - drug effects Pancreatitis Pancreatitis, Chronic - drug therapy Parenchyma Physiological aspects Proteins Pulmonary fibrosis Rats Real-Time Polymerase Chain Reaction Risk factors Rodents Scars Signaling Smooth muscle Stellate cells Transforming growth factor-b Tumor necrosis factor-TNF
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!