Epigenetic regulation of αA-crystallin in high myopia-induced dark nuclear cataract

To assess the etiology of early-onset dark nucleus in high-myopic patients and its relationship with the epigenetic regulation of αA-crystallin (CRYAA). We reviewed clinical data from patients who underwent cataract surgery at our center in 2012. Lens epithelial samples were collected during capsulo...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e81900-e81900
Hauptverfasser:	Zhu, Xiang-Jia, Zhou, Peng, Zhang, Ke-Ke, Yang, Jin, Luo, Yi, Lu, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged alpha-Crystallin A Chain - genetics Apoptosis Boscia Cataract - etiology Cataract - genetics Cataracts Confidence intervals CpG islands CpG Islands - genetics Crystal structure Crystallin Crystallinity Deoxyribonucleic acid Diabetes DNA DNA Methylation Epigenesis, Genetic Epigenetics Epithelium Epithelium - metabolism Etiology Eye surgery Female Gene expression Glaucoma Humans Immunohistochemistry Islands Lens, Crystalline - metabolism Lenses Male Middle Aged Myopia Myopia - complications Nuclei Opacity Patients Polymerase chain reaction Promoter Regions, Genetic - genetics Proteins Reverse transcription Risk Factors Statistical analysis Statistical methods Studies Surgery
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