DNase γ is the effector endonuclease for internucleosomal DNA fragmentation in necrosis

Apoptosis and necrosis, two major forms of cell death, can be distinguished morphologically and biochemically. Internucleosomal DNA fragmentation (INDF) is a biochemical hallmark of apoptosis, and caspase-activated DNase (CAD), also known as DNA fragmentation factor 40 kDa (DFF40), is one of the maj...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e80223
Hauptverfasser:	Mizuta, Ryushin, Araki, Shinsuke, Furukawa, Makoto, Furukawa, Yuki, Ebara, Syota, Shiokawa, Daisuke, Hayashi, Katsuhiko, Tanuma, Sei-ichi, Kitamura, Daisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Animals Apoptosis Biochemistry Calcium Cancer Caspase Cell death Cell lines Cytotoxicity Deoxyribonuclease Deoxyribonucleases - genetics Deoxyribonucleases - metabolism Deoxyribonucleic acid DNA DNA Fragmentation Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Endonuclease Endoplasmic reticulum Fragmentation Gangrene Humans Magnesium Mice Necrosis Pharmaceutical sciences Physiology Poly-ADP-Ribose Binding Proteins Rodents U937 Cells
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